Stephen A. Harrison Clinical Gastroenterology and Hepatology

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Presentation transcript:

Insulin Resistance Among Patients With Chronic Hepatitis C: Etiology and Impact on Treatment Stephen A. Harrison Clinical Gastroenterology and Hepatology Volume 6, Issue 8, Pages 864-876 (August 2008) DOI: 10.1016/j.cgh.2008.03.024 Copyright © 2008 AGA Institute Terms and Conditions

Figure 1 Insulin resistance, hepatic steatosis, and advanced fibrosis/cirrhosis. Clinical Gastroenterology and Hepatology 2008 6, 864-876DOI: (10.1016/j.cgh.2008.03.024) Copyright © 2008 AGA Institute Terms and Conditions

Figure 2 Proposed molecular pathways involved in the development of insulin resistance in patients with hepatitis C. aRecent evidence indicates that leptin and adiponectin do not account for the increased insulin resistance found in patients with CHC.53 Additional studies are required to confirm the role of adipocytokines in patients with chronic hepatitis. FAS, fatty acid synthetase; MTP, microsomal triglyceride transfer protein; PP2Ac, protein phosphatase 2Ac; SREBP-1, sterol response element-binding protein-1. Clinical Gastroenterology and Hepatology 2008 6, 864-876DOI: (10.1016/j.cgh.2008.03.024) Copyright © 2008 AGA Institute Terms and Conditions