Fig. 3. Features of PH in KRasLA2 transgenic mice.

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Fig. 3. Features of PH in KRasLA2 transgenic mice.

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Fig. 3. Features of PH in KRasLA2 transgenic mice. Features of PH in KRasLA2 transgenic mice. (A) Schematic of the experimental design. Measurements of 3-, 4-, and 5-month-old WT and KRasLA2 lung tumor–bearing mice. (B) Representative hematoxylin and eosin–stained sections of mouse lungs. Scale bar, 500 μm. (C) Echocardiographic measurements. (D) Physiological measurements of RVSP, SAP, PO2, and PVR of the mice. For WT, n = 7; for KRasLA2, n = 10. (E) Representative photomicrographs of vWF (brown)–stained and α-SMA (violet)–stained tissues, followed by (F) quantification of pulmonary vascular muscularization (given as a percentage for each range of vessel sizes). Scale bars, 20 μm. (G) Representative photomicrographs of elastica van Gieson–stained tissues, followed by (H) quantification of medial wall thickness of pulmonary vessels. Scale bars, 20 μm. (I) Representative photomicrographs of Sirius red staining (right). Scale bars, 20 μm. Quantitative image analysis of Sirius red staining (collagen deposition) in the RV (left). For WT, n = 7; for KRasLA2, n = 10. *P < 0.05, **P < 0.01, ***P < 0.001 compared with WT; §P < 0.05, §§P < 0.01, §§§P < 0.001 compared with nontumor regions of KRasLA2. Soni Savai Pullamsetti et al., Sci Transl Med 2017;9:eaai9048 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works