Real-life compliance and persistence among users of subcutaneous and sublingual allergen immunotherapy Menno A. Kiel, MD, MSc, Esther Röder, MD, PhD,

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Presentation transcript:

Real-life compliance and persistence among users of subcutaneous and sublingual allergen immunotherapy Menno A. Kiel, MD, MSc, Esther Röder, MD, PhD, Roy Gerth van Wijk, MD, PhD, Maiwenn J. Al, PhD, Wim C.J. Hop, PhD, Maureen P.M.H. Rutten-van Mölken, PhD Journal of Allergy and Clinical Immunology Volume 132, Issue 2, Pages 353-360.e2 (August 2013) DOI: 10.1016/j.jaci.2013.03.013 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Behavior in 4 patients attempting to fulfill a full 3-year course of immunotherapy (IT; simplified). Each vertical marker equals 3 months or one quarter of a year, which in this example equals 1 package of immunotherapy vials or tablets. DI, Dispensing interval; (max.) perm. gap, (maximum) permissible gap. Patient A is both compliant and persistent. Patient B is noncompliant but persistent. Patient C is nonpersistent and therefore noncompliant. Patient D is both noncompliant and nonpersistent. Journal of Allergy and Clinical Immunology 2013 132, 353-360.e2DOI: (10.1016/j.jaci.2013.03.013) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Kaplan-Meier curves and summaries of time to treatment discontinuation by route of administration (A), allergen (B), and prescriber (C). P values of predictor level distribution equality are less than .001 (right censored for deceased and relocated cases). Journal of Allergy and Clinical Immunology 2013 132, 353-360.e2DOI: (10.1016/j.jaci.2013.03.013) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 A, Kaplan-Meier curves and summaries of time to treatment discontinuation by sex (right censored for deceased and relocated cases). B, Kaplan-Meier curves and summaries of time to treatment discontinuation by geographic location of residence (right censored for deceased and relocated cases). C, Kaplan-Meier curves and summaries of time to treatment discontinuation by age quartile. Quartiles around sample median (44 years) are as follows: quartile I, 33 years or less; quartile II, 35 to 43 years; quartile III, 44 to 51 years, and quartile IV, 53 years or greater (right censored for deceased and relocated cases). D, Kaplan-Meier curves and summaries of time to treatment discontinuation by SES factor score. Quartiles are around the sample median (−1.64), with the first quartile as the reference category (0) compared with quartiles 2 through 4 (1). Higher quartile numbers have lower SES (factor score). Journal of Allergy and Clinical Immunology 2013 132, 353-360.e2DOI: (10.1016/j.jaci.2013.03.013) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions