The effect of anti-IgE treatment on in vitro leukotriene release in children with seasonal allergic rhinitis Matthias Volkmar Kopp, MDa, Jens Brauburger,

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Presentation transcript:

The effect of anti-IgE treatment on in vitro leukotriene release in children with seasonal allergic rhinitis Matthias Volkmar Kopp, MDa, Jens Brauburger, MDb, Frank Riedinger, MDa, Dorothee Beischer a, Gabriele Ihorst, MSca, Wolfgang Kamin, MDc, Stefan Zielen, MDd, Christina Bez, MD d, Frank Friedrichs, MDe, Andrea von Berg, MDf, Kerstin Gerhold, MDg, Eckard Hamelmann, MDg, Thomas Hultsch, MD c, Joachim Kuehr, MDa Journal of Allergy and Clinical Immunology Volume 110, Issue 5, Pages 728-735 (November 2002) DOI: 10.1067/mai.2002.128804 Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 1 Study design. BS, Time point of blood sampling. Journal of Allergy and Clinical Immunology 2002 110, 728-735DOI: (10.1067/mai.2002.128804) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 2 In vitro SLT release (in nanograms per liter) after stimulation with grass pollen allergen and birch pollen allergen in the groups treated with grass SIT plus anti-IgE (A) and grass SIT plus placebo (B) before and after therapy. The boxes include the interval between the 25th and 75th percentiles. The extremes represent the 5th and 95th percentiles. The median is shown as a horizontal line in the box and the mean as an asterisk . A statistically significant difference was observed when comparing the SLT release before and after therapy in response to grass (P = .0001) and birch (P = .0002) allergen in the grass SIT plus anti-IgE group but not in the grass SIT plus placebo group. Journal of Allergy and Clinical Immunology 2002 110, 728-735DOI: (10.1067/mai.2002.128804) Copyright © 2002 Mosby, Inc. Terms and Conditions

Fig. 3 In vitro SLT release (in nanograms per liter) after stimulation with grass pollen allergen and birch pollen allergen in the groups treated with birch SIT plus anti-IgE (A) and birch SIT plus placebo (B) before and after therapy. The boxes include the interval between the 25th and 75th percentiles. The extremes represent the 5th and 95th percentiles. The median is shown as a horizontal line in the box and the mean as an asterisk . A statistically significant difference was observed when comparing the SLT release before and after therapy in response to grass (P = .0011) and birch (P = .0001) allergen in the birch SIT plus anti-IgE group but not in the grass SIT plus placebo group. Journal of Allergy and Clinical Immunology 2002 110, 728-735DOI: (10.1067/mai.2002.128804) Copyright © 2002 Mosby, Inc. Terms and Conditions