Risk Estimation in Type 2 Myocardial Infarction and Myocardial Injury: The TARRACO Risk Score German Cediel, MD, PhD, Yader Sandoval, MD, Anne Sexter,

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Presentation transcript:

Risk Estimation in Type 2 Myocardial Infarction and Myocardial Injury: The TARRACO Risk Score German Cediel, MD, PhD, Yader Sandoval, MD, Anne Sexter, MPH, Anna Carrasquer, MD, Maribel González-del-Hoyo, MD, Gil Bonet, MD, Carme Boqué, MD, PhD, Karen Schulz, DC, Stephen W. Smith, MD, Antoni Bayes-Genis, MD, PhD, Fred S. Apple, PhD, Alfredo Bardaji, MD, PhD The American Journal of Medicine Volume 132, Issue 2, Pages 217-226 (February 2019) DOI: 10.1016/j.amjmed.2018.10.022 Copyright © 2018 Terms and Conditions

Figure 1 Flowchart of patient selection for the 2 study cohorts. MI = myocardial infarction. The American Journal of Medicine 2019 132, 217-226DOI: (10.1016/j.amjmed.2018.10.022) Copyright © 2018 Terms and Conditions

Figure 2 Derivation of the TARRACO Risk Score, based on a stepwise multivariable regression analysis, for predicting the risk of major adverse cardiovascular events among patients with type 2 myocardial infarction or myocardial injury. (Left, upper panel) First, the odds ratio for each variable was rounded to an integer, then these integers were assigned to each variable (1 to 3 points each). The total scores (maximum = 13) were divided into 2 risk categories, (left, lower panel) low risk (0 to 6 points) and high risk (7 to 13 points). (Right) Kaplan-Meier analysis of 180-day major adverse cardiovascular events and mortality showed significantly higher rates of major adverse cardiovascular events in the high-risk (gold) group compared with the low-risk (blue) group (derivation cohort). MACE = major adverse cardiovascular events. The American Journal of Medicine 2019 132, 217-226DOI: (10.1016/j.amjmed.2018.10.022) Copyright © 2018 Terms and Conditions

Figure 3 Derivation cohort calibration plot. The derivation cohort was divided into 9 groups of predicted probability of major adverse cardiovascular events. Subsequently, calibration was assessed by plotting the predicted probability of major adverse cardiovascular events against the observed frequency of major adverse cardiovascular events. The American Journal of Medicine 2019 132, 217-226DOI: (10.1016/j.amjmed.2018.10.022) Copyright © 2018 Terms and Conditions

Figure 4 Kaplan-Meier curves depict the incidence of major adverse cardiovascular events, according to risk categories, in the external validation cohort. The American Journal of Medicine 2019 132, 217-226DOI: (10.1016/j.amjmed.2018.10.022) Copyright © 2018 Terms and Conditions

Figure 5 The TARRACO Risk Scores increased with increasing major adverse cardiovascular events incidence. The percentages of major adverse cardiovascular events observed in subgroups based on TARRACO Risk Scores are shown for the derivation (blue) and validation (gold) cohorts. The American Journal of Medicine 2019 132, 217-226DOI: (10.1016/j.amjmed.2018.10.022) Copyright © 2018 Terms and Conditions