Fig. 6. TIV-09, but not MIV-09, induces an IFN signature in the blood of vaccinated individuals at day 1. TIV-09, but not MIV-09, induces an IFN signature.

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Fig. 6. TIV-09, but not MIV-09, induces an IFN signature in the blood of vaccinated individuals at day 1. TIV-09, but not MIV-09, induces an IFN signature in the blood of vaccinated individuals at day 1. Healthy individuals were vaccinated at t = 0 hour with saline, TIV-09, or MIV-09 (n = 3 per group), and blood was drawn at 0, 1.5, 3, 6, 9, 12, 15, 24, and 36 hours and 2, 3, and 7 days. Data were normalized to the median of the t = 0 hour samples across donors. Transcripts from three IFN blood modules (M1.2, M3.4, and M5.12) (36) were selected for analysis. Both transcript- and module-level analyses are displayed. Module expression is calculated as the percentage of transcripts from a specific module that are over- or underexpressed under a specific condition as compared to the t = 0 hour reference control. Shruti Athale et al., Sci Transl Med 2017;9:eaaf9194 Copyright © 2017, American Association for the Advancement of Science