Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: Entering a new century, do we do better?

Slides:

Advertisements

Similar presentations

Treosulfan-based conditioning regimens for hematopoietic stem cell transplantation in children with primary immunodeficiency: United Kingdom experience.

Advertisements

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Induced pluripotent stem cells: A novel frontier in the study of human primary immunodeficiencies Itai M. Pessach, MD, PhD, Jose Ordovas-Montanes, BA,

Multicenter experience in hematopoietic stem cell transplantation for serious complications of common variable immunodeficiency Claudia Wehr, MD, Andrew.

Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies.

Clarification concerning amoxicillin skin testing

Physical health conditions and quality of life in adults with primary immunodeficiency diagnosed during childhood: A French Reference Center for PIDs.

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Immunologic defects in 22q11.2 deletion syndrome

Effect of stem cell source on long-term chimerism and event-free survival in children with primary immunodeficiency disorders after fludarabine and melphalan.

Long-term immune reconstitution after matched unrelated hematopoietic stem cell transplantation for immunodeficiency Vy Hong-Diep Kim, MD, Brenda Reid,

Incident asthma and Mycoplasma pneumoniae: A nationwide cohort study

Is 9 more than 2 also in allergic airway inflammation?

Outcomes of patients with severe combined immunodeficiency treated with hematopoietic stem cell transplantation with and without preconditioning Niraj.

Functional changes in gut microbiota during hematopoietic stem cell transplantation for severe combined immunodeficiency Jonathan P. Lane, MBBS, Christopher.

Long-term immune reconstitution and clinical outcome after stem cell transplantation for severe T-cell immunodeficiency Evelina Mazzolari, MD, Concetta.

Hospitalization rates and prognosis of patients with anaphylactic shock in Denmark from 1995 through 2012 Anni Nørgaard Jeppesen, MD, Christian Fynbo.

Occurrence of myelodysplastic syndrome in 2 patients with reticular dysgenesis Chantal Lagresle-Peyrou, PhD, Bénédicte Neven, MD, Emmanuelle Six, PhD,

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Physician needs in health informatics: Just ask the docs

Outcome of domino hematopoietic stem cell transplantation in human subjects: An international case series Mirjam E. Belderbos, MD, PhD, Andrew R. Gennery,

Gut microbiome variations during hematopoietic stem cell transplant in severe combined immunodeficiency Jonathan P. Lane, MBBS, Christopher J. Stewart,

Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency Waleed Al-Herz, MD, Julia I. Chu, MD, Jet.

Nonadherence to Asthma Treatment: Getting Unstuck

Peter M. Wolfgram, MD, David B. Allen, MD

Late thymic deficiency after HLA-haploidentical hematopoietic stem cell transplantation for severe combined immunodeficiency Markus J. Ege, MD, Catharina.

Treosulfan and Fludarabine Conditioning for Hematopoietic Stem Cell Transplantation in Children with Primary Immunodeficiency: UK Experience Mary A.

Practice pattern changes and improvements in hematopoietic cell transplantation for primary immunodeficiencies Rebecca A. Marsh, MD, Kyle M. Hebert,

Debra J. Palmer, PhD, Thomas R. Sullivan, BMa&CompSc(Hons), Michael S

Intranasal triamcinolone use during pregnancy and the risk of adverse pregnancy outcomes Anick Bérard, MSc, PhD, Odile Sheehy, MSc, Marie-Laure Kurzinger,

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Infection with a respiratory virus before hematopoietic cell transplantation is associated with alloimmune-mediated lung syndromes Birgitta Versluys,

Food allergy in patients with primary immunodeficiency diseases: Prevalence within the US Immunodeficiency Network (USIDNET) Karen S. Tuano, MD, Jordan.

What are the best outcome measurements for atopic eczema

Long-term outcomes of nonconditioned patients with severe combined immunodeficiency transplanted with HLA-identical or haploidentical bone marrow depleted.

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Host natural killer immunity is a key indicator of permissiveness for donor cell engraftment in patients with severe combined immunodeficiency Amel Hassan,

William T. Shearer, MD, PhD, Alain Fischer, MD, PhD

What is an “eosinophilic phenotype” of asthma?

Medication use in children with asthma in Finland from 1995 to 2006

T-cell receptor αβ+ and CD19+ cell–depleted haploidentical and mismatched hematopoietic stem cell transplantation in primary immune deficiency Ravi M.

Combined liver and hematopoietic stem cell transplantation in patients with X-linked hyper-IgM syndrome Giorgia Bucciol, MD, Sarah K. Nicholas, MD, Pier.

Autophagy: Nobel Prize 2016 and allergy and asthma research

Higher incidence of pediatric anaphylaxis in northern areas of the United States William J. Sheehan, MD, Dionne Graham, PhD, Lin Ma, MS, Sachin Baxi,

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

Geographic variability in childhood asthma prevalence in Chicago

Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L

Hematopoietic stem cell transplantation for CD40 ligand deficiency: Results from an EBMT/ESID-IEWP-SCETIDE-PIDTC study Francesca Ferrua, MD, Stefania.

CD45RA depletion in HLA-mismatched allogeneic hematopoietic stem cell transplantation for primary combined immunodeficiency: A preliminary study Fabien.

Benjamin Chaigne, MD, Hervé Watier, MD, PhD

Signal transducer and activator of transcription 5 tyrosine phosphorylation for the diagnosis and monitoring of patients with severe combined immunodeficiency

George Philip, MD, Carolyn M

Advances in basic and clinical immunology in 2013

Macrolide antibiotics and asthma treatment

Asthma: The past, future, environment, and costs

Severe cutaneous human papillomavirus infection associated with natural killer cell deficiency following stem cell transplantation for severe combined.

Janet Chou, MD, Maxim Lutskiy, MD, PhD, Erdyni Tsitsikov, PhD, Luigi D

Outcome of hematopoietic stem cell transplantation for adenosine deaminase–deficient severe combined immunodeficiency by Amel Hassan, Claire Booth, Alex.

Environmental factors and eosinophilic esophagitis

Confirmation and improvement of criteria for clinical phenotyping in common variable immunodeficiency disorders in replicate cohorts Helen Chapel, MA,

Hematopoietic stem cell transplantation for CD3δ deficiency

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Liver disease predicts mortality in patients with X-linked immunodeficiency with hyper- IgM but can be prevented by early hematopoietic stem cell transplantation

Presentation transcript:

Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: Entering a new century, do we do better? Andrew R. Gennery, MD, Mary A. Slatter, MD, Laure Grandin, MSc, Pierre Taupin, MD, Andrew J. Cant, FRCP, Paul Veys, FRCP, Persis J. Amrolia, FRCP, H. Bobby Gaspar, PhD, E. Graham Davies, FRCPCH, Wilhelm Friedrich, PhD, Manfred Hoenig, MD, Luigi D. Notarangelo, MD, Evelina Mazzolari, MD, Fulvio Porta, MD, Robbert G.M. Bredius, PhD, Arjen C. Lankester, PhD, Nico M. Wulffraat, PhD, Reinhard Seger, MD, Tayfun Güngör, MD, Anders Fasth, PhD, Petr Sedlacek, PhD, Benedicte Neven, MD, Stephane Blanche, MD, Alain Fischer, PhD, Marina Cavazzana-Calvo, PhD, Paul Landais, PhD Journal of Allergy and Clinical Immunology Volume 126, Issue 3, Pages 602-610.e11 (September 2010) DOI: 10.1016/j.jaci.2010.06.015 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Cumulative probability of survival in patients with SCID after HSCT according to the period in which transplanted, donor source (related or URD), and HLA matching. MMR, Mismatched related; RGI, related genoidentical; RPI, related phenoidentical. Journal of Allergy and Clinical Immunology 2010 126, 602-610.e11DOI: (10.1016/j.jaci.2010.06.015) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Cumulative probability of survival in patients with T-B- or T- B+ SCID after HSCT through all periods. Journal of Allergy and Clinical Immunology 2010 126, 602-610.e11DOI: (10.1016/j.jaci.2010.06.015) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Cumulative probability of survival in patients with non-SCID PID after HSCT according to the period in which transplanted, donor source (related or URD), and HLA matching and type of immunodeficiency through all periods. MMR, Mismatched related; RGI, related genoidentical; RPI, related phenoidentical. Journal of Allergy and Clinical Immunology 2010 126, 602-610.e11DOI: (10.1016/j.jaci.2010.06.015) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Cumulative probability of survival in patients with SCID after HSCT according to year at grafting in HLA-mismatched SCID. Journal of Allergy and Clinical Immunology 2010 126, 602-610.e11DOI: (10.1016/j.jaci.2010.06.015) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Cumulative probability of survival in patients with SCID after HSCT according to donor source (related or URD) and HLA matching for the period 2000 to 2005. MMR, Mismatched related; RGI, related genoidentical; RPI, related phenoidentical. Journal of Allergy and Clinical Immunology 2010 126, 602-610.e11DOI: (10.1016/j.jaci.2010.06.015) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Cumulative probability of survival in patients with SCID after HSCT according to age at transplantation through all periods. Journal of Allergy and Clinical Immunology 2010 126, 602-610.e11DOI: (10.1016/j.jaci.2010.06.015) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Cumulative probability of survival in patients with non-SCID PID after HSCT according to donor source (related or URD) and HLA matching for the period 2000 to 2005. MMR, Mismatched related; RGI, related genoidentical; RPI, related phenoidentical. Journal of Allergy and Clinical Immunology 2010 126, 602-610.e11DOI: (10.1016/j.jaci.2010.06.015) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Cumulative probability of survival in patients with non-SCID PID after HSCT according to type of T-cell deficiency for the period 1995 to 2005. Journal of Allergy and Clinical Immunology 2010 126, 602-610.e11DOI: (10.1016/j.jaci.2010.06.015) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions