Effect of sialyl Lewisx oligosaccharide on myocardial and cerebral injury in the pig Motohisa Tofukuji, MD, PhD, Caroline Metais, MD, Charles D Collard,

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Presentation transcript:

Effect of sialyl Lewisx oligosaccharide on myocardial and cerebral injury in the pig Motohisa Tofukuji, MD, PhD, Caroline Metais, MD, Charles D Collard, MD, David S Morse, MD, Gregory L Stahl, PhD, David P Nelson, MD, Jian Li, MD, Michael Simons, MD, Frank W Sellke, MD The Annals of Thoracic Surgery Volume 67, Issue 1, Pages 112-119 (January 1999) DOI: 10.1016/S0003-4975(98)01130-8

Fig 1 In vitro responses of precontracted porcine coronary microvessels to the endothelium-dependent vasodilator ADP from control hearts and hearts after ischemia–cardioplegia in the saline and CY-1503 groups. Responses are expressed as percent relaxation of acetylcholine-induced precontraction. (ADP-adenosine 5′-diphosphate.) ∗∗p < 0.01 versus control. The Annals of Thoracic Surgery 1999 67, 112-119DOI: (10.1016/S0003-4975(98)01130-8)

Fig 2 In vitro responses of precontracted porcine coronary microvessels to the endothelium-independent cyclic GMP-mediated vasodilator sodium mitroprusside (SNP) from control hearts and hearts after ischemia–cardioplegia in the saline and CY-1503 groups. Responses are expressed as percent relaxation of acetylcholine-induced precontraction. The Annals of Thoracic Surgery 1999 67, 112-119DOI: (10.1016/S0003-4975(98)01130-8)

Fig 3 In vitro responses of precontracted porcine brain microvessels to the endothelium-dependent vasodilator ADP from control hearts and hearts in the saline and CY-1503 groups after ischemia–cardioplegia. Responses are expressed as percent relaxation of U46619-induced precontraction. (ADP-adenosine 5′-diphosphate.) ∗p < 0.05 versus control. The Annals of Thoracic Surgery 1999 67, 112-119DOI: (10.1016/S0003-4975(98)01130-8)

Fig 4 In vitro responses of precontracted porcine brain microvessels to the endothelium-independent cyclic GMP-mediated vasodilator sodium nitroprusside (SNP) from control hearts and hearts in the saline and CY-1503 groups after ischemia–cardioplegia. Responses are expressed as percent relaxation of U46619-induced precontraction. The Annals of Thoracic Surgery 1999 67, 112-119DOI: (10.1016/S0003-4975(98)01130-8)

Fig 5 Representative reverse transcriptase polymerase chain reaction products of cNOS and iNOS in the porcine heart, shown in GAPDH-stained 1.5% agarose gel for amount of RNA control. The Annals of Thoracic Surgery 1999 67, 112-119DOI: (10.1016/S0003-4975(98)01130-8)