Volume 85, Issue 3, Pages 496-498 (March 2014) β-Lapachone ameliorates murine cisplatin nephrotoxicity: NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation  Christopher Y. Lu  Kidney International  Volume 85, Issue 3, Pages 496-498 (March 2014) DOI: 10.1038/ki.2013.419 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 β-Lapachone, NQO1, NAD+, and SIRT1 at the crossroads of metabolism, injury, and inflammation during cisplatin nephrotoxicity. Blue arrows and blue boxes show processes elucidated by Oh et al.1 Red arrows show additional processes that may be involved in cisplatin nephrotoxicity. AKI, acute kidney injury; ARE, antioxidant response element; ER, endoplasmic reticulum; Keap, Kelch-like ECH-associated protein 1; NADH, nicotinamide adenine dinucleotide; NF-κB, nuclear factor-κB; NQO1, NAD+(P)H:quinone oxidoreductase 1; Nrf2, nuclear factor-erythroid 2-related factor 2; PARP1, poly-(ADP-ribose) polymerase-1; ROS, reactive oxygen species; SIRT1, sirtuin 1 (silent information regulator 2 (Sir2) protein 1). Kidney International 2014 85, 496-498DOI: (10.1038/ki.2013.419) Copyright © 2014 International Society of Nephrology Terms and Conditions