Volume 72, Issue 6, Pages (September 2007)

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Volume 72, Issue 6, Pages 690-697 (September 2007) Protocol biopsies in renal transplantation: Prognostic value of structural monitoring D. Serón, F. Moreso Kidney International Volume 72, Issue 6, Pages 690-697 (September 2007) DOI: 10.1038/sj.ki.5002396 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Estimation of minimum sample size in an hypothetical clinical trial to detect a 50% reduction in the incidence of IF/TA. For power calculation, it was assumed a 16% prevalence of IF/TA in the preimplantation biopsy, 38% in the protocol biopsy of the control group, and 27% in the protocol biopsy of the treatment group. It was estimated that 285 cases per group would be necessary to detect a difference between groups (α=0.05 and β=0.20). Kidney International 2007 72, 690-697DOI: (10.1038/sj.ki.5002396) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 2 Relationship between the prevalence of IF/TA in the control and minimum sample size to detect a 50% reduction in the prevalence of IF/TA in the study group. Kidney International 2007 72, 690-697DOI: (10.1038/sj.ki.5002396) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 3 Quantification of cortical interstitial volume fraction in a normal and diseased renal allograft biopsies by means of a point counting technique (silver methenamine stain, original magnification × 200). Kidney International 2007 72, 690-697DOI: (10.1038/sj.ki.5002396) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 4 Quantification of sirius red-positive area in a normal and diseased renal allograft biopsy by means of image analysis technique (original magnification × 100). Kidney International 2007 72, 690-697DOI: (10.1038/sj.ki.5002396) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 5 Quantification of intimal arterial volume fraction by means of a point counting technique in a normal artery and an artery with transplant vasculopathy (Masson's tricrome, original magnification × 400). Kidney International 2007 72, 690-697DOI: (10.1038/sj.ki.5002396) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 6 Correlation and Bland-Altman plots showing interobserver variability for the estimation of mean glomerular volume (Vg) and mean intimal arterial volume fraction (Vvint/art). Kidney International 2007 72, 690-697DOI: (10.1038/sj.ki.5002396) Copyright © 2007 International Society of Nephrology Terms and Conditions