Bradykinin increases the in vivo expression of the CXC chemokine receptors CXCR1 and CXCR2 in patients with allergic rhinitis Jane Eddleston, PhD, Sandra.

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Bradykinin increases the in vivo expression of the CXC chemokine receptors CXCR1 and CXCR2 in patients with allergic rhinitis Jane Eddleston, PhD, Sandra C. Christiansen, MD, Gavin R. Jenkins, PhD, James A. Koziol, PhD, Bruce L. Zuraw, MD Journal of Allergy and Clinical Immunology Volume 111, Issue 1, Pages 106-112 (January 2003) DOI: 10.1067/mai.2003.19 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 Increased levels of CXCR1 and CXCR2 mRNA in the nasal tissue of patients with active allergic rhinitis. Nasal tissue was obtained from 13 patients with active allergic rhinitis (active AR) ; 11 patients with mild, quiescent allergic rhinitis (mild AR) ; and 13 healthy control subjects. Total RNA was isolated, and each sample was analyzed in triplicate for CXCR1, CXCR2, and GAPDH by means of real-time quantitative RT-PCR. Levels of CXC chemokine receptor mRNA were normalized to GAPDH. An induction index was calculated for each sample. The induction index is defined as the ratio of the chemokine mRNA expression in a given sample divided by the mean chemokine mRNA expression of the matched healthy control subjects. The levels of CXCR1 (A) and CXCR2 (B) mRNA levels were compared between the subjects groups. Journal of Allergy and Clinical Immunology 2003 111, 106-112DOI: (10.1067/mai.2003.19) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 Effect of nasal bradykinin on the in vivo level of CXCR1 and CXCR2 mRNA in human nasal tissue. Patients with allergic rhinitis (AR) and healthy control subjects (NS) were challenged with intranasal bradykinin (200 μg), and nasal tissue was obtained 4 or 8 hours later. Total RNA was isolated, and each sample was analyzed in triplicate for CXCR1, CXCR2, and GAPDH expression by means of real-time quantitative RT-PCR. Levels of CXCR1 and CXCR2 mRNA were normalized to GAPDH. Each subject is represented by a different shape, with open shapes representing the level of induction of either CXCR1 (A) or CXCR2 (B) mRNA at 4 hours, and filled shapes representing the level of induction of CXCR mRNA after 8 hours compared with the matched baseline level of CXCR mRNA. Journal of Allergy and Clinical Immunology 2003 111, 106-112DOI: (10.1067/mai.2003.19) Copyright © 2003 Mosby, Inc. Terms and Conditions