Early and Late Extensive Chronic Graft-versus-Host Disease in Children Is Characterized by Different Th1/Th2 Cytokine Profiles: Findings of the Children's.

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Presentation transcript:

Early and Late Extensive Chronic Graft-versus-Host Disease in Children Is Characterized by Different Th1/Th2 Cytokine Profiles: Findings of the Children's Oncology Group Study ASCT0031 Jacob Rozmus, Kirk R. Schultz, Kristin Wynne, Amina Kariminia, Preeti Satyanarayana, Mark Krailo, Stephan A. Grupp, Andrew L. Gilman, Frederick D. Goldman Biology of Blood and Marrow Transplantation Volume 17, Issue 12, Pages 1804-1813 (December 2011) DOI: 10.1016/j.bbmt.2011.05.011 Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 (A) IFN-γ mRNA production at early and late time points in controls and patients with cGVHD after PI stimulation for 18 hours. (B) IFN-γ mRNA production at early and late time points in controls and patients with cGVHD after anti-CD3 mAb stimulation for 18 hours. (C) IL-2 mRNA production at early and late time points in controls and patients with cGVHD after PI stimulation for 18 hours. (D) IL-2 mRNA production at early and late time points in controls and patients with cGVHD after anti-CD3 mAb stimulation for 18 hours. (E) IL-4 mRNA production at early and late time points in controls and patients with cGVHD after PI stimulation for 18 hours. (F) IL-4 mRNA production at early and late time points in controls and patients with cGVHD after anti-CD3 mAb stimulation for 18 hours. (G) IL-10 mRNA production at early and late time points in controls and patients with cGVHD after anti-CD3 mAb stimulation for 18 hours. Biology of Blood and Marrow Transplantation 2011 17, 1804-1813DOI: (10.1016/j.bbmt.2011.05.011) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 (A) ROC curve analysis of IFN-γ mRNA production after PI stimulation for predicting the absence of early cGVHD. (B) ROC curve analysis of IL-2 mRNA production after anti-CD3 stimulation for predicting the absence of late cGVHD. (C) ROC curve analysis of IL-4 mRNA production after anti-CD3 stimulation for predicting the absence of late cGVHD. Biology of Blood and Marrow Transplantation 2011 17, 1804-1813DOI: (10.1016/j.bbmt.2011.05.011) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 (A) Foxp3 production at early and late time points in controls and patients with cGVHD in unstimulated samples. (B) Foxp3 production at early and late time points in controls and patients with cGVHD after anti-CD3 mAb stimulation for 18 hours. Biology of Blood and Marrow Transplantation 2011 17, 1804-1813DOI: (10.1016/j.bbmt.2011.05.011) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions