Volume 56, Issue 2, Pages (August 1999)

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Volume 56, Issue 2, Pages 414-420 (August 1999) Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats Surasak Kantachuvesiri, Chris S. Haley, Stewart Fleming, Katarna Kurian, Caroline E. Whitworth, Philip Wenham, Yuri Kotelevtsev, John J. Mullins Kidney International Volume 56, Issue 2, Pages 414-420 (August 1999) DOI: 10.1046/j.1523-1755.1999.00571.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Distribution of age at time of death of the progeny of TGRmRen2-27 and F1 (Fischer-Lewis). Out of 252 male progeny, 200 had died by 120 days in total over a range of 49 to 119 days. The median age at time of death was 60 days, with a mean of 63.3 days ±SD 12.2 days. Kidney International 1999 56, 414-420DOI: (10.1046/j.1523-1755.1999.00571.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Histopathology of kidney. The kidneys of animals exhibiting clinical symptoms of malignant hypertension show myointimal proliferation and fibrinoid necrosis of arteries and arterioles. (A) Hematoxylin and eosin. (B) Martius Scarlet Blue. Kidney International 1999 56, 414-420DOI: (10.1046/j.1523-1755.1999.00571.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Tail cuff systolic blood pressure (SBP) measurement of the progeny of TGRmRen2-27 and F1 (Fischer-Lewis) prior to the development of malignant hypertension (MH). Data are expressed as mean ±SEM. Symbols are: (•) MH; (□) survivors. Kidney International 1999 56, 414-420DOI: (10.1046/j.1523-1755.1999.00571.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 4 LOD score of the markers on chromosomes 10 (A) and 17 (B). The highest LOD scores were found close to the Ace and At1 loci. LOD values for the traits survival (broken line) and age of death (AoD; solid line) are from interval mapping analysis17,18. The broken, horizontal line is the LOD threshold for significant linkage19 (cM, centiMorgan). Kidney International 1999 56, 414-420DOI: (10.1046/j.1523-1755.1999.00571.x) Copyright © 1999 International Society of Nephrology Terms and Conditions