IRF4 expression regulates the sensitivity of CD8+ T cells to IL-2, IL-15, and IL-7. IRF4 expression regulates the sensitivity of CD8+ T cells to IL-2,

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IRF4 regulates cytokine receptor expression in CD8+ T cells.

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Presentation transcript:

IRF4 expression regulates the sensitivity of CD8+ T cells to IL-2, IL-15, and IL-7. IRF4 expression regulates the sensitivity of CD8+ T cells to IL-2, IL-15, and IL-7. (A) Purified control (Irf4 fl/fl) or IRF4-deficient CD8+ T cells were activated in vitro with increasing amounts of human IL-2 in the presence of neutralizing mouse IL-2 Ab. Live CD8+ T cell numbers were determined daily following activation. (B) Purified control (Irf4 fl/fl) or IRF4-deficient CD8+ T cells were activated in vitro with increasing amounts of IL-7. Live CD8+ T cell numbers were determined daily following activation. (C) Purified control (Irf4 fl/fl) or IRF4-deficient CD8+ T cells were activated with increasing amount of IL-15. Live CD8+ T cell numbers were determined daily following activation. Data are representative of two independent experiments. Su Huang et al. ImmunoHorizons 2017;1:92-100 Copyright © 2017 The Authors