Potency of menthol depends on L9´ residue size.

Slides:

Advertisements

Similar presentations

Volume 96, Issue 1, Pages (January 2009)

Advertisements

Extension of the GlyRβ binding site on gephyrin.

Fig. 3. Frequencies of amino acids at critical PGT121 and contact sites in the SHIV-SF162P3 challenge stock. Frequencies of amino acids at critical.

Phosphorylation of a tyrosine residue in mGluR1a-CT1 by Fyn.

Salt Effects on Ionization Equilibria of Histidines in Myoglobin

different predicted values (D)

Volume 74, Issue 1, Pages (January 1998)

Active avoidance is impaired in aged mice in both multimodal and visual versions of the task. Active avoidance is impaired in aged mice in both multimodal.

Examples of sagittal histologic images and color-coded maps from 3

A–E, Active avoidance (A–D) and optokinetic testing (E) in an independent cohort. A–E, Active avoidance (A–D) and optokinetic testing (E) in an independent.

Implicit adaptation generalizes around the aiming location (30° CCW)

αβ T Cell Receptor Ligand-Specific Oligomerization Revisited

Simon W. Rabkin et al. JACEP 2017;3:

Examples of coronal maps derived from the reconstructed 3D volume.

Examples of sagittal histologic images and color-coded maps from 7

(A) Scatter plot representing the difference between YPAQ-derived MVPA and accelerometer-derived MVPA plotted against the criterion method (accelerometer);

Megakaryocyte total surface area increases with protrusion extension.

Changes in WM diffusion parameters with increasing age along the length of HG from medial (primary) to lateral (nonprimary). Changes in WM diffusion parameters.

Uncaging responses in spines that are below the optical measurement threshold: clear optical bAP measurements serve as positive controls and for signal.

Sequences of two isoforms of Arhgap39/Porf-2 protein in mouse.

MPP+-induced toxicity in cultured SN and VTA DA neurons.

Repolarization of membrane potential is associated with a decreased membrane conductance. Repolarization of membrane potential is associated with a decreased.

Scatter plot of body mass index (BMI) versus forced expiratory volume in the first second (FEV1), and linear correlation lines for normal spirometry and.

Spatial statistics of X-ray volumes reveal layering and spatially diverse distribution of cell bodies. Spatial statistics of X-ray volumes reveal layering.

HIV Broadly Neutralizing Antibodies: Taking Good Care Of The 98%

Computed Pore Potentials of the Nicotinic Acetylcholine Receptor

Leptin-induced LTP at TA-CA1 synapses involves a postsynaptic expression mechanism. Leptin-induced LTP at TA-CA1 synapses involves a postsynaptic expression.

CRISPRa sgRNA multiplexing for synergistic or coordinated control of gene expression. CRISPRa sgRNA multiplexing for synergistic or coordinated control.

Kv2. 1-like currents are related linearly to estimates of Kv2

Alternative model for FMRP phosphorylation and regulation of translation. Alternative model for FMRP phosphorylation and regulation of translation. FMRP.

A, Rewarded voluntary switch task, a combined risky decision-making and task-switching paradigm. A, Rewarded voluntary switch task, a combined risky decision-making.

Activation of glial cells.

Results of CFC training and testing.

Relationship between hippocampal volume and the number of reported episodic and nonepisodic details. Relationship between hippocampal volume and the number.

Log10-transformed EEG power in the 0- to 30-Hz range measured in females (white) and males (gray) at each channel for NFB (left) and CAL (right), shown.

Dror Sharon, Michael A. Sandberg, Vivian W

Changes in the extent of swim recovery correlated with polysynaptic actions. Changes in the extent of swim recovery correlated with polysynaptic actions.

Repetition suppression: Interaction between trials without (prime) versus with (target) context (C) and repeated versus non-repeated context (i.e., repetition.

The Fisher information predicts the experimentally measured sensitivity. The Fisher information predicts the experimentally measured sensitivity. A, Sensitivity.

Example of the response characteristics of an ILD-sensitive neuron in the DNLL. A, Raster plots show sustained responses (cell_230207_05; BF = 2500 Hz)

Molecular Mechanism of Antibody-Mediated Activation of β-galactosidase

Tuning width distributions.

Averaged LSPS-induced excitation maps obtained from pyramidal and fast-spiking neurons in Layer II/III IC of sham and 1w-IANX rats. Averaged LSPS-induced.

Exploration of deletion variant dose-dependent effects of reboxetine on enhanced memory for negative pictures and gene dose-dependent effects. 0 indicates.

Surround integration and suppression in the direction domain.

Analysis of individual full cells.

3DMorph workflow. 3DMorph workflow. The user selects either Interactive or Automatic mode. Interactive mode must be used first to generate a parameters.

Analysis of potential contribution of spike timing to plasticity.

Reclined functional residual capacity (FRC) predicts cough inspired volume, which in turn predicts cough flow. Reclined functional residual capacity (FRC)

Dissection and clearing of brain subregions.

A FD model explaining latency of MT cell activation.

nAChR β2 antibody labeling in WT and β2 KO mouse model.

Summary data for target shift experiments and transient recall of old memories observed in the second target shift task. Summary data for target shift.

Calibration of the voltage dependence of spine ΔF/F using optical recordings in spines of bAPs. Calibration of the voltage dependence of spine ΔF/F using.

Depiction of wild-type and mutated Hes6 proteins.

A, B, Startle magnitude and PPI after treatment with CNO

CRISPRa induction of Bdnf mRNA increases spike and burst frequency in hippocampal neurons cultured on microelectrode arrays (MEAs). CRISPRa induction of.

Elimination of dendritic spines per 2 d.

The dopamine (DA) response to cocaine infusion in the NAc in constitutive p11 KO mice is restored by nicotinic or muscarinic receptor stimulation in the.

Power spectra of EMG during the pre- and post-feedback sessions.

Grand-averaged ERPs across (A) left hemisphere electrodes (P5, P7, P9, PO3, PO7, and O1) and (B) right hemisphere electrodes (P6, P8, P10, PO4, PO8, and.

PNU enhances Ca2+ flux mediated by an engineered variant of the human α7 nAChR. PNU enhances Ca2+ flux mediated by an engineered variant.

Acute applications display only slight pharmacological differences among menthol stereoisomers. Acute applications display only slight pharmacological.

A, The ratio of currents elicited by an EC50 concentration of ACh and 100 µm menthol over the current elicited by ACh alone. A, The ratio of currents elicited.

Activation and desensitization of the α7 nAChRs.

Changes in 44-hour interdialytic systolic BP as a function of change in echocardiographic volume parameter. Changes in 44-hour interdialytic systolic BP.

Sensorimotor cortex recordings have a canonical shape.

Fig. 19 Comparisons between sky brightness NPS CCD observations and atlas predictions. Comparisons between sky brightness NPS CCD observations and atlas.

Sequence alignment of colicin lysis proteins.

αβ T Cell Receptor Ligand-Specific Oligomerization Revisited

Presentation transcript:

Potency of menthol depends on L9´ residue size. Potency of menthol depends on L9´ residue size. A1–B2, Plot of IC40 for (−)-menthol versus residue length (A1) or residue volume (B1) and plot of IC30 for (+)-menthol versus residue length (A2) or residue volume (B2). C1, Fitting the IC40 values for (−)-menthol against the reduced AA index. C2, Fitting the IC30 values for (+)-menthol against the reduced AA index. R2 values in C1 and C2 for each parameter are indicated in extended Figures 7-1 and 7-2. D, Concentration–response relationship for (−)-menthol on (α4[L9´I])3(β2)2 and (α4[L9´O-Me-Thr])3(β2)2 nAChRs. Structures of the two amino acids are shown to the left along with their end-to-end length; n = 7–18 oocytes. Brandon J. Henderson et al. eNeuro 2018;5:ENEURO.0465-18.2018 ©2018 by Society for Neuroscience