Cytokine responses in cord blood predict the severity of later respiratory syncytial virus infection Hanna Juntti, MD, Pamela Österlund, PhD, Jorma Kokkonen,

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Cytokine responses in cord blood predict the severity of later respiratory syncytial virus infection Hanna Juntti, MD, Pamela Österlund, PhD, Jorma Kokkonen, MD, Teija Dunder, MD, Marjo Renko, MD, Tytti Pokka, BSc, Ilkka Julkunen, MD, Matti Uhari, MD Journal of Allergy and Clinical Immunology Volume 124, Issue 1, Pages 52-58.e2 (July 2009) DOI: 10.1016/j.jaci.2009.04.014 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Flow sheet of the study profile. Cord blood data were not available for all the infants because of a lack of samples or inadequate amounts of mononuclear cells in some samples. Journal of Allergy and Clinical Immunology 2009 124, 52-58.e2DOI: (10.1016/j.jaci.2009.04.014) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Cytokine responses in LPS-stimulated CBMCs, with significant differences between the groups. RSVH, Hospitalized patients with RSV; RSVO, patients with RSV treated as outpatients; other, control subjects with some other respiratory viral infection; healthy, healthy control subjects. IFN-γ: P = .009, RSVH versus healthy group. IL-6: P < .001, RSVH versus RSVO and other P = .001, RSVH versus healthy group. Journal of Allergy and Clinical Immunology 2009 124, 52-58.e2DOI: (10.1016/j.jaci.2009.04.014) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Cytokine responses in unstimulated CBMCs, with significant differences between the groups. RSVH, hospitalized patients with RSV; RSVO, patients with RSV treated as outpatients; other, control subjects with some other respiratory viral infection; healthy, healthy control subjects. IFN-γ: P = .03, RSVH versus healthy group. IL-4: P = .03, RSVH versus other P = .01, RSVH versus healthy group. IL-6: P = .002, RSVH versus healthy group. IL-12: P = .003, RSVH versus healthy group. Journal of Allergy and Clinical Immunology 2009 124, 52-58.e2DOI: (10.1016/j.jaci.2009.04.014) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions