CD11c+HLADR+ dendritic cells are present in human ovarian follicular fluid, and their maturity correlates with serum estradiol levels in response to gonadotropins

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CD11c+HLADR+ dendritic cells are present in human ovarian follicular fluid, and their maturity correlates with serum estradiol levels in response to gonadotropins Ofer Fainaru, M.D., Ph.D., Shay Hantisteanu, M.Sc., Nechami Rotfarb, B.Sc., Medeia Michaeli, Ph.D., Mordechai Hallak, M.D., Adrian Ellenbogen, M.D. Fertility and Sterility Volume 97, Issue 3, Pages 702-706 (March 2012) DOI: 10.1016/j.fertnstert.2011.12.030 Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 1 DCs are present in ovarian FF. Single-cell suspensions of ovarian FF were analyzed by flow cytometry. The CD45+ bone marrow–derived leukocyte population is gated (A), and the CD11c+HLADR+ DC population is demonstrated (B). (C) The DC population in FFs derived from all patients; mean ± SEM (n = 30). Fertility and Sterility 2012 97, 702-706DOI: (10.1016/j.fertnstert.2011.12.030) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 2 DC maturation status correlates with the ovarian response to gonadotropins. The MFI of HLADR expression, reflecting DC maturity, is plotted against ovarian response as determined by serum levels of E2 at the day of hCG administration in (A) all patients (n = 30) and in (B) male factor patients (n = 10). R = Pearson correlate. Fertility and Sterility 2012 97, 702-706DOI: (10.1016/j.fertnstert.2011.12.030) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions

Figure 3 FF DC presence is influenced by the presence of an endometrioma. FF CD45+ leukocytes are gated (top) in a patient with a unilateral endometrioma. DCs are completely absent in FF derived from an ovarian follicle adjacent to an endometrioma (bottom right), while they were highly abundant in FF derived from a follicle in the contralateral ovary (bottom left). Fertility and Sterility 2012 97, 702-706DOI: (10.1016/j.fertnstert.2011.12.030) Copyright © 2012 American Society for Reproductive Medicine Terms and Conditions