Peritoneal fluid-mediated enhancement of eutopic and ectopic endometrial cell proliferation is dependent on tumor necrosis factor-α in women with endometriosis

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Presentation transcript:

Peritoneal fluid-mediated enhancement of eutopic and ectopic endometrial cell proliferation is dependent on tumor necrosis factor-α in women with endometriosis Donald P Braun, Ph.D., Jianchi Ding, Ph.D., W.Paul Dmowski, M.D., Ph.D. Fertility and Sterility Volume 78, Issue 4, Pages 727-732 (October 2002) DOI: 10.1016/S0015-0282(02)03318-6

FIGURE 1 Effect of autologous peritoneal fluid (PF) on endometrial cell (Endo) proliferation in fertile controls (Cont) and patients with endometriosis. Eutopic and ectopic endometrial cells from endometriosis patients, and eutopic endometrial cells from controls were incubated in the absence (−PF) and presence (+PF) of autologous peritoneal fluid for 72 hours before addition of 3H-thymidine for 24 hours and assessment of incorporation of label in cellular DNA by liquid scintillation counting. Braun. TNF and endometrium in endometriosis. Fertil Steril 2002. Fertility and Sterility 2002 78, 727-732DOI: (10.1016/S0015-0282(02)03318-6)

FIGURE 2 Effect of heterologous peritoneal fluid (PF) from patients with endometriosis on eutopic endometrial cell (Endo) proliferation. Eutopic endometrial cells from four patients with endometriosis (A) and four controls (B) were incubated for 72 hours in the presence of peritoneal fluids from four unrelated patients with endometriosis (PF-endo1, PF-endo2, PF-endo3, and PF-endo4) before addition of 3H-thymidine for 24 hours and assessment of incorporation of label in cellular DNA by liquid scintillation counting. Braun. TNF and endometrium in endometriosis. Fertil Steril 2002. Fertility and Sterility 2002 78, 727-732DOI: (10.1016/S0015-0282(02)03318-6)

FIGURE 3 Effect of the soluble tumor necrosis factor (TNF) receptor etanercept on enhancement of eutopic and ectopic endometrial cell proliferation by peritoneal fluid (PF) in women with endometriosis. Endometrial cells were incubated in the absence (−PF) or presence (+PF) of autologous peritoneal fluid, with and without etanercept, for 72 hours before addition of 3H-thymidine for 24 hours and assessment of incorporation of label in cellular DNA by liquid scintillation counting. The effect of etanercept in the absence of peritoneal fluid was negligible, and data are therefore not shown. Braun. TNF and endometrium in endometriosis. Fertil Steril 2002. Fertility and Sterility 2002 78, 727-732DOI: (10.1016/S0015-0282(02)03318-6)