Adiponectin: Starving for Attention

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Adiponectin: Starving for Attention Gregory R. Steinberg, Bruce E. Kemp Cell Metabolism Volume 6, Issue 1, Pages 3-4 (July 2007) DOI: 10.1016/j.cmet.2007.06.008 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Appetite Control by Adiponectin Fasting triggers increased adiponectin in the cerebrospinal fluid (CSF) and activation of AMPK in the brain, which increases NPY and induces feeding (green arrows). Feeding reduces adiponectin and lowers appetite (red arrows). In obesity, the capacity to lower adiponectin in response to feeding is suppressed, preventing the switching off of appetite (dashed red arrow). CAMKK2, Ca2+/calmodulin-dependent protein kinase kinase 2β; ACC, acetyl-CoA carboxylase; FACoA, long-chain fatty acyl-CoA; NPY, neuropeptide Y; ?, unknown pathway. Cell Metabolism 2007 6, 3-4DOI: (10.1016/j.cmet.2007.06.008) Copyright © 2007 Elsevier Inc. Terms and Conditions