Polarized arrest with warm or cold adenosine/lidocaine blood cardioplegia is equivalent to hypothermic potassium blood cardioplegia Joel S. Corvera,

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Presentation transcript:

Polarized arrest with warm or cold adenosine/lidocaine blood cardioplegia is equivalent to hypothermic potassium blood cardioplegia Joel S. Corvera, MD, Hajime Kin, MD, PhD, Geoffrey P. Dobson, PhD, Faraz Kerendi, MD, Michael E. Halkos, MD, Sara Katzmark, BS, Christopher S. Payne, BS, Zhi-Qing Zhao, MD, PhD, Robert A. Guyton, MD, Jakob Vinten-Johansen, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 129, Issue 3, Pages 599-606 (March 2005) DOI: 10.1016/j.jtcvs.2004.07.021 Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 End-systolic pressure/dimension relationship at baseline and during reperfusion. ESPDR, Slope of the end-systolic pressure/dimension relationship during transient caval occlusion, an index of global left ventricular contractility. R60, R90, and R120, 60, 90, and 120 minutes of reperfusion, respectively. The Journal of Thoracic and Cardiovascular Surgery 2005 129, 599-606DOI: (10.1016/j.jtcvs.2004.07.021) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Left ventricular preload recruitable stroke work during baseline and reperfusion, derived from pressure/minor axis diameter data. PRSW, Preload recruitable stroke work; R60, R90, and R120, 60, 90, and 120 minutes of reperfusion, respectively. The Journal of Thoracic and Cardiovascular Surgery 2005 129, 599-606DOI: (10.1016/j.jtcvs.2004.07.021) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Left ventricular end-diastolic pressure/dimension relationship as a measure of global left ventricular stiffness. β, Modulus of diastolic stiffness obtained by fitting successive end-diastolic pressure points obtained during transient caval occlusion to a curve, an inverse index of left ventricular compliance; R60, R90, and R120, 60, 90, and 120 minutes of reperfusion, respectively. †P < .05 versus baseline values by repeated-measures ANOVA. The Journal of Thoracic and Cardiovascular Surgery 2005 129, 599-606DOI: (10.1016/j.jtcvs.2004.07.021) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Plasma creatine kinase activity during the course of the experiment. CPB, Sampled 5 minutes after initiation of CPB; BCP1, sampled at the end of the induction BCP infusion; BCP2 and BCP3, sampled at the end of intermittent BCP infusions; BCP4, sampled at the end of terminal BCP infusion; R60, R90, and R120, sampled at 60, 90, and 120 minutes of reperfusion, respectively. *P < .05 for cold AL-BCP versus K+-BCP at R60. The Journal of Thoracic and Cardiovascular Surgery 2005 129, 599-606DOI: (10.1016/j.jtcvs.2004.07.021) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 Postexperimental left anterior descending (LAD) coronary artery endothelial and smooth muscle function. Maximal relaxation responses to acetylcholine (ACh), calcium ionophore A23187 (A23), and sodium nitroprusside (SNP) are shown in postexperimentally excised epicardial LAD coronary arteries. Maximum values were determined from stepwise incremental concentrations of each drug. The Journal of Thoracic and Cardiovascular Surgery 2005 129, 599-606DOI: (10.1016/j.jtcvs.2004.07.021) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions