Defective response to insulin secretagogues may arise from A) decreased concentrations of a given secretagogue, B) loss of β-cell responsiveness to that.

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Defective response to insulin secretagogues may arise from A) decreased concentrations of a given secretagogue, B) loss of β-cell responsiveness to that secretagogue (defective sensing), or C) a partial inability of β-cells to secrete insulin in response to stimulation. Defective response to insulin secretagogues may arise from A) decreased concentrations of a given secretagogue, B) loss of β-cell responsiveness to that secretagogue (defective sensing), or C) a partial inability of β-cells to secrete insulin in response to stimulation. Adrian Vella, and Claudio Cobelli Diabetes 2015;64:2324-2325 ©2015 by American Diabetes Association