IL-13 induces eosinophil recruitment into the lung by an IL-5– and eotaxin-dependent mechanism Samuel M. Pope, BAa,b, Eric B. Brandt, PhDa, Anil Mishra,

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IL-13 induces eosinophil recruitment into the lung by an IL-5– and eotaxin-dependent mechanism Samuel M. Pope, BAa,b, Eric B. Brandt, PhDa, Anil Mishra, PhDa, Simon P. Hogan, PhDa,c, Nives Zimmermann, MDa, Klaus I. Matthaei, PhDc, Paul S. Foster, PhDc, Marc E. Rothenberg, MD, PhDa Journal of Allergy and Clinical Immunology Volume 108, Issue 4, Pages 594-601 (October 2001) DOI: 10.1067/mai.2001.118600 Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 1 Kinetic analysis of IL-13–induced leukocytes in BALF. Mice received intranasal treatment with 10 μg/day of either IL-13 or control saline solution. The total leukocyte (A ), eosinophil (B ), and neutrophil (C ) levels in BALF 18 hours after the day of cytokine administration are shown. Results are expressed as means ± SDs. Because of the small number of mice examined at each time point, statistical analysis was not performed for this initial kinetic analysis. Journal of Allergy and Clinical Immunology 2001 108, 594-601DOI: (10.1067/mai.2001.118600) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 2 IL-13–induced eosinophil counts in BALF. Mice were treated for 10 days with IL-13 (solid) or saline solution (hatched) . The total eosinophil levels (A ) and eosinophil percentages (B ) in BALF of wild-type (n = 10), eotaxin –/– (n = 14), IL-5 –/– (n = 9), eotaxin/IL-5–double-deficient (Eot/IL-5 –/–; n = 10), and IL-5 transgenic (Tg ; n = 6) mice were determined. The results are data pooled from 3 experiments and are expressed as means ± SDs. Journal of Allergy and Clinical Immunology 2001 108, 594-601DOI: (10.1067/mai.2001.118600) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 3 IL-13–induced lung tissue eosinophilia. Mice were treated for 10 consecutive days with saline solution (hatched) or IL-13 (solid) . The level of eosinophils in the lung tissue was determined by morphometric analysis from wild-type (n = 5), eotaxin –/– (n = 8), IL-5 –/– (n = 8), eotaxin/IL-5–double-deficient (Eot/IL-5 –/–; n = 10), and IL-5 transgenic (Tg ; n = 4) mice. The results are data pooled from 2 representative experiments and are expressed as means ± SDs. Journal of Allergy and Clinical Immunology 2001 108, 594-601DOI: (10.1067/mai.2001.118600) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 4 Photomicrographs of saline solution– and IL-13–treated lung sections stained with anti-MBP. Mice were treated for 10 consecutive days with saline solution or IL-13, and representative sections from wild-type (A, B ), IL-5 –/– (C, D ), IL-5 transgenic (tg ; E, F ), and eotaxin –/– (G, H ) mice are shown. In panels A through H , sections are stained with anti-MBP and eosinophils are identified as black-stained cells. The arrows point to representative MBP-positive eosinophils. Eosinophils are observable only in saline solution–treated IL-5 transgenic (E ), IL-13 treated wild-type (B ), and IL-5 transgenic (F ) mice. Journal of Allergy and Clinical Immunology 2001 108, 594-601DOI: (10.1067/mai.2001.118600) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 5 IL-13–induced mucus production. Mice were treated for 10 consecutive days with saline solution (hatched) or IL-13 (solid), and the percentage of epithelium positive for mucus (after periodic-acid Schiff staining) is shown from wild-type (n = 5), eotaxin –/– (n = 6), IL-5 –/– (n = 8), eotaxin/IL-5–double-deficient (Eot/IL-5 –/–; n = 6), and IL-5 transgenic (Tg ; n = 5) mice. The results are data pooled from 2 representative experiments and are expressed as means ± SDs. Journal of Allergy and Clinical Immunology 2001 108, 594-601DOI: (10.1067/mai.2001.118600) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 6 Photomicrographs of saline solution– and IL-13–treated lung sections stained for mucus. Mice were treated for 10 consecutive days with saline solution (A ) or IL-13 (B ); representative lung sections from wild-type mice are shown. Sections were stained with periodic-acid Schiff stain, and mucus-expressing cells are identified as purple-staining cells, seen primarily in the IL-13 treated mice. Journal of Allergy and Clinical Immunology 2001 108, 594-601DOI: (10.1067/mai.2001.118600) Copyright © 2001 Mosby, Inc. Terms and Conditions