Incremental Cost-Effectiveness Ratio (ICER) exponentially decreases as the duration of wear increases. Incremental Cost-Effectiveness Ratio (ICER) exponentially decreases as the duration of wear increases. Compared with no treatment, the unloader knee brace can be considered cost-effective within the NICE threshold for duration of wear of 4 months or more. NICE, National Institute for Health and Care Excellence. Paul YF Lee et al. BMJ Open Sport Exerc Med 2017;2:e000195 ©2017 by BMJ Publishing Group Ltd