Human and mouse islets express MCH and MCHR1.

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Human and mouse islets express MCH and MCHR1. Human and mouse islets express MCH and MCHR1. Quantitative real-time PCR for MCH and MCHR1 in human islets and human brain (A) and mouse islets, mouse brain, and mouse β-cell line βTC3 and mouse hypothalamus (B). C: Immunohistochemistry of mouse pancreas sections stained for MCH using DAB substrate (two independent islets are shown in left upper and lower panels) and MCHR1 (right upper panel) as described in research design and methods. A magnified image of immunostaining for MCHR1 is shown in the right lower panel. Arrows point to areas of immunostaining. Pavlos Pissios et al. Diabetes 2007;56:311-319 ©2007 by American Diabetes Association