A Commensal Protozoan Strikes a Balance in the Gut

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A Commensal Protozoan Strikes a Balance in the Gut P’ng Loke, Yvonne A.L. Lim Cell Host & Microbe Volume 20, Issue 4, Pages 417-419 (October 2016) DOI: 10.1016/j.chom.2016.09.016 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Effects of T.mu Colonization Colonization of mice by the protozoan parasite Tritrichomonas musculis triggers inflammasome activation in intestinal epithelial cells, resulting in the production of IL-18. This promotes the differentiation of TH1 and TH17 cells in the gut, which leads to enhanced anti-bacterial defenses that can suppress the pathological effects of Salmonella Typhimurium infection. However, T.mu-colonized mice are then more susceptible to intestinal inflammation and colorectal cancer. Cell Host & Microbe 2016 20, 417-419DOI: (10.1016/j.chom.2016.09.016) Copyright © 2016 Elsevier Inc. Terms and Conditions