The Effect of Oral PC-III on Osteoarthritis and Bone Marrow Lesions

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Presentation transcript:

The Effect of Oral PC-III on Osteoarthritis and Bone Marrow Lesions A.J. Kiraly, S. Talic, A. Sun, D.R. Mauerhan, E.N. Hanley, Y. Sun Osteoarthritis and Cartilage Volume 25, Pages S313-S314 (April 2017) DOI: 10.1016/j.joca.2017.02.525 Copyright © 2017 Terms and Conditions

Figure 1: The articular cartilage and subchondral bone changes between PC-III treated animals and control at 3, 6, 12, 18 months. Osteoarthritis and Cartilage 2017 25, S313-S314DOI: (10.1016/j.joca.2017.02.525) Copyright © 2017 Terms and Conditions

Figure 2: Histological analysis of bone marrow lesions in Hartley guinea pigs. A – Graphical representation of average grade assigned based off of grading scale. B – Photo of bone marrow of a control animal at 3 months, C and D are examples of found bone marrow lesions. C – Fibrosis (black arrow). D – Encapsulated (red arrow) and non-encapsulated (black arrow) necrosis. Osteoarthritis and Cartilage 2017 25, S313-S314DOI: (10.1016/j.joca.2017.02.525) Copyright © 2017 Terms and Conditions