The Lancet Global Health

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The Lancet Global Health Evaluation of integrated interventions layered on mass drug administration for urogenital schistosomiasis elimination: a cluster-randomised trial Stefanie Knopp, PhD, Bobbie Person, PhD, Shaali M Ame, PhD, Said M Ali, MSc, Jan Hattendorf, PhD, Saleh Juma, MSc, Juma Muhsin, MD, Iddi S Khamis, MSc, Khalfan A Mohammed, PhD, Prof Jürg Utzinger, PhD, Elizabeth Hollenberg, MSc, Fatma Kabole, MD, David Rollinson, PhD The Lancet Global Health DOI: 10.1016/S2214-109X(19)30189-5 Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 1 Trial profile Shehia=small administrative region. MDA=mass drug administration. The Lancet Global Health DOI: (10.1016/S2214-109X(19)30189-5) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 2 Timeline of interventions and surveys SBT=school-based treatment. CWT=community-wide treatment. *In Pemba, in round 6, community-wide treatment was done by means of health posts. The Lancet Global Health DOI: (10.1016/S2214-109X(19)30189-5) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 3 Schistosoma haematobium prevalence in 45 schools on each of the two study islands from 2012 to 2017 Colours from red to green indicate the change in prevalence from high to low. Letters indicate the three different study arms. M=biannual praziquantel mass drug administration (MDA) only. B=behaviour change plus biannual praziquantel MDA. S=snail control plus biannual praziquantel MDA. The Lancet Global Health DOI: (10.1016/S2214-109X(19)30189-5) Copyright © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions