Evidence that enhanced nasal reactivity to bradykinin in patients with symptomatic allergy is mediated by neural reflexes Margerita M. Riccio, PhD, David.

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Evidence that enhanced nasal reactivity to bradykinin in patients with symptomatic allergy is mediated by neural reflexes Margerita M. Riccio, PhD, David Proud, PhD Journal of Allergy and Clinical Immunology Volume 97, Issue 6, Pages 1252-1263 (June 1996) DOI: 10.1016/S0091-6749(96)70193-8 Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 Effect of nasal provocation with bradykinin in nonallergic subjects (filled circles; n = 9) and patients with perennial allergy (open circles; n = 10). Panels at left represent ipsilateral responses, and panels at right show contralateral responses. A, Secretion weights. Bradykinin induced a significant increase in ipsilateral secretions in both patients with perennial allergy (p < 0.01) and nonallergic subjects (p < 0.05), although the response was significantly greater in the group with perennial allergy (p < 0.01). Bradykinin induced significant contralateral responses in patients with perennial allergy (p < 0.01) but not in the nonallergic subjects. B, Lactoferrin levels. Bradykinin induced significant (p < 0.05 in each case) increases in ipsilateral and contralateral lactoferrin secretions in the patients with perennial allergy but not in the nonallergic subjects. C, Albumin levels. Bradykinin induced significant (p < 0.001 in each case) increases in ipsilateral albumin secretions in the patients with perennial allergy and nonallergic subjects, which were not significantly different between the two groups. Modest increases in contralateral secretion of albumin achieved significance for nonallergic subjects (p < 0.001) but not for patients with perennial allergy (p = 0.06). Journal of Allergy and Clinical Immunology 1996 97, 1252-1263DOI: (10.1016/S0091-6749(96)70193-8) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 Effect of nasal provocation with bradykinin in nonallergic subjects (filled circles; n = 9) and patients with perennial allergy (open circles; n = 10). Panels at left represent ipsilateral responses, and panels at right show contralateral responses. A, Secretion weights. Bradykinin induced a significant increase in ipsilateral secretions in both patients with perennial allergy (p < 0.01) and nonallergic subjects (p < 0.05), although the response was significantly greater in the group with perennial allergy (p < 0.01). Bradykinin induced significant contralateral responses in patients with perennial allergy (p < 0.01) but not in the nonallergic subjects. B, Lactoferrin levels. Bradykinin induced significant (p < 0.05 in each case) increases in ipsilateral and contralateral lactoferrin secretions in the patients with perennial allergy but not in the nonallergic subjects. C, Albumin levels. Bradykinin induced significant (p < 0.001 in each case) increases in ipsilateral albumin secretions in the patients with perennial allergy and nonallergic subjects, which were not significantly different between the two groups. Modest increases in contralateral secretion of albumin achieved significance for nonallergic subjects (p < 0.001) but not for patients with perennial allergy (p = 0.06). Journal of Allergy and Clinical Immunology 1996 97, 1252-1263DOI: (10.1016/S0091-6749(96)70193-8) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 Effect of nasal provocation with bradykinin in nonallergic subjects (filled circles; n = 9) and patients with perennial allergy (open circles; n = 10). Panels at left represent ipsilateral responses, and panels at right show contralateral responses. A, Secretion weights. Bradykinin induced a significant increase in ipsilateral secretions in both patients with perennial allergy (p < 0.01) and nonallergic subjects (p < 0.05), although the response was significantly greater in the group with perennial allergy (p < 0.01). Bradykinin induced significant contralateral responses in patients with perennial allergy (p < 0.01) but not in the nonallergic subjects. B, Lactoferrin levels. Bradykinin induced significant (p < 0.05 in each case) increases in ipsilateral and contralateral lactoferrin secretions in the patients with perennial allergy but not in the nonallergic subjects. C, Albumin levels. Bradykinin induced significant (p < 0.001 in each case) increases in ipsilateral albumin secretions in the patients with perennial allergy and nonallergic subjects, which were not significantly different between the two groups. Modest increases in contralateral secretion of albumin achieved significance for nonallergic subjects (p < 0.001) but not for patients with perennial allergy (p = 0.06). Journal of Allergy and Clinical Immunology 1996 97, 1252-1263DOI: (10.1016/S0091-6749(96)70193-8) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Effect of nasal provocation with bradykinin in patients with seasonal allergy (n = 9) challenged in season (open circles) and out of season (filled circles). Panels at left represent ipsilateral responses, and panels at right show contralateral responses. A, Secretion weights. Bradykinin induced significant increases (p < 0.001 in each case) in ipsilateral secretions in subjects challenged both in season and out of season, but the increase was significantly greater during the season (p < 0.01). A significant increase in contralateral secretion weights was seen in the subjects challenged in season (p < 0.01) but not out of season. B, Lactoferrin levels. Bradykinin did not stimulate either ipsilateral or contralateral production of lactoferrin when subjects were challenged out of season. When subjects were challenged in season, bradykinin induced significant increases in ipsilateral (p < 0.01) and contralateral (p < 0.05) lactoferrin levels. C, Albumin levels. Bradykinin induced significant (p < 0.001 in each case) increases in ipsilateral albumin secretions in the subjects challenged both in and out of season, which were not significantly different between the two groups. Bradykinin challenge did not cause a significant contralateral secretion of albumin in subjects challenged in season or out of season. Journal of Allergy and Clinical Immunology 1996 97, 1252-1263DOI: (10.1016/S0091-6749(96)70193-8) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Effect of nasal provocation with bradykinin in patients with seasonal allergy (n = 9) challenged in season (open circles) and out of season (filled circles). Panels at left represent ipsilateral responses, and panels at right show contralateral responses. A, Secretion weights. Bradykinin induced significant increases (p < 0.001 in each case) in ipsilateral secretions in subjects challenged both in season and out of season, but the increase was significantly greater during the season (p < 0.01). A significant increase in contralateral secretion weights was seen in the subjects challenged in season (p < 0.01) but not out of season. B, Lactoferrin levels. Bradykinin did not stimulate either ipsilateral or contralateral production of lactoferrin when subjects were challenged out of season. When subjects were challenged in season, bradykinin induced significant increases in ipsilateral (p < 0.01) and contralateral (p < 0.05) lactoferrin levels. C, Albumin levels. Bradykinin induced significant (p < 0.001 in each case) increases in ipsilateral albumin secretions in the subjects challenged both in and out of season, which were not significantly different between the two groups. Bradykinin challenge did not cause a significant contralateral secretion of albumin in subjects challenged in season or out of season. Journal of Allergy and Clinical Immunology 1996 97, 1252-1263DOI: (10.1016/S0091-6749(96)70193-8) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Effect of nasal provocation with bradykinin in patients with seasonal allergy (n = 9) challenged in season (open circles) and out of season (filled circles). Panels at left represent ipsilateral responses, and panels at right show contralateral responses. A, Secretion weights. Bradykinin induced significant increases (p < 0.001 in each case) in ipsilateral secretions in subjects challenged both in season and out of season, but the increase was significantly greater during the season (p < 0.01). A significant increase in contralateral secretion weights was seen in the subjects challenged in season (p < 0.01) but not out of season. B, Lactoferrin levels. Bradykinin did not stimulate either ipsilateral or contralateral production of lactoferrin when subjects were challenged out of season. When subjects were challenged in season, bradykinin induced significant increases in ipsilateral (p < 0.01) and contralateral (p < 0.05) lactoferrin levels. C, Albumin levels. Bradykinin induced significant (p < 0.001 in each case) increases in ipsilateral albumin secretions in the subjects challenged both in and out of season, which were not significantly different between the two groups. Bradykinin challenge did not cause a significant contralateral secretion of albumin in subjects challenged in season or out of season. Journal of Allergy and Clinical Immunology 1996 97, 1252-1263DOI: (10.1016/S0091-6749(96)70193-8) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 Effects of pretreatment of the contralateral nostril with atropine (0.32 mg) or placebo on the ipsilateral and contralateral glandular responses to unilateral challenge with a single dose (30 μg) of bradykinin. Panels at left represent ipsilateral responses, and panels at right show contralateral responses. A, Secretion weights. B, Lactoferrin levels. Atropine significantly (*p < 0.05 in each case) attenuated the contralateral increases in secretion weights and lactoferrin levels induced by bradykinin provocation without altering ipsilateral responses. Journal of Allergy and Clinical Immunology 1996 97, 1252-1263DOI: (10.1016/S0091-6749(96)70193-8) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 Effects of pretreatment of the contralateral nostril with atropine (0.32 mg) or placebo on the ipsilateral and contralateral glandular responses to unilateral challenge with a single dose (30 μg) of bradykinin. Panels at left represent ipsilateral responses, and panels at right show contralateral responses. A, Secretion weights. B, Lactoferrin levels. Atropine significantly (*p < 0.05 in each case) attenuated the contralateral increases in secretion weights and lactoferrin levels induced by bradykinin provocation without altering ipsilateral responses. Journal of Allergy and Clinical Immunology 1996 97, 1252-1263DOI: (10.1016/S0091-6749(96)70193-8) Copyright © 1996 Mosby, Inc. Terms and Conditions