Expression of T-bet and GATA-3 in early mycosis fungoides and spongiotic dermatitis Amira Elbendary, MBBCh, MSc, Kruti Parikh, BS, Inas Elattar, DrPH,

Slides:

Advertisements

Similar presentations

Lauren Kwa, BA, Jonathan I. Silverberg, MD, PhD, MPH

Advertisements

CD47 expression for in situ and invasive cutaneous epithelial lesions

A 52-year-old man with bullous pemphigoid and bullous cystitis

Volume 1, Issue 4, Pages (July 2015)

Yul W. Yang, MD, PhD, David J. DiCaudo, MD

Diffuse hyperpigmented plaques as cutaneous manifestation of multicentric Castleman disease and treatment with thalidomide: Report of three cases Xiaoqing.

Baldness reversed by chemotherapy

CME examination Journal of the American Academy of Dermatology

Expression of PD-L1 in mastocytosis

Array of cutaneous adverse effects associated with sorafenib

Idiopathic eruptive macular pigmentation associated with pregnancy and Hashimoto thyroiditis Danica Milobratovic, MD, Sanja Djordjevic, MD, Jelica Vukicevic,

Extensive ulcerated pigmented nodules

The importance of lymph node examination: Simultaneous diagnosis of hypopigmented mycosis fungoides and follicular B-cell lymphoma Mathew X. Joseph,

Negative results of patch testing with standard and textile series in a case of annular lichenoid dermatitis of youth Carlos de la Torre, MD, PhD, Ángeles.

Comparing the sensitivity of auramine-rhodamine fluorescence to polymerase chain reaction in the detection of Mycobacterium leprae in Fite-negative tissue.

Iatrogenic hyperpigmentation in chronically infected hepatitis C patients treated with pegylated interferon and ribavirin Jennifer Lin, MD, Jason P.

Surveillance and assessment of occupational dermatitis using Rhode Island workers' compensation data 1998 to 2002 Irwin B. Horwitz, PhD, Brian P. McCall,

Cynthia M. Magro, MD, Tracy L. Davis, MD, PhD, Drew J.B. Kurtzman, MD

Ben Tallon, MBChB, Elizabeth Blanchard, MD, Lynne J. Goldberg, MD

Rapid deterioration in a patient with primary aggressive cutaneous epidermotropic CD8+ cytotoxic T-cell (‘Berti’) lymphoma after administration of adalimumab

Squamous cell carcinoma tumor thrombus encountered during Mohs micrographic surgery Gary Mendese, MD, Jeremy Bordeaux, MD, MPH, Sean Pattee, MD, Mary.

Ming Yang Bi, AB, Jonathan L. Curry, MD, Angela M

Clinicopathologic features and T-cell receptor gene rearrangement findings of mycosis fungoides palmaris et plantaris Sang-Tae Kim, MD, Young-Seung Jeon,

Atypical lymphocytic reaction with epidermotropism and lymphocytic vasculopathic reaction (lymphocytic vasculitis) after treatment with imiquimod Jesús.

Volume 3, Issue 2, Pages (March 2017)

Volume 1, Issue 4, Pages (July 2015)

Jonathan E. Blume, MD, Howard L. Stoll, MD, Richard T. Cheney, MD

Katherine E. Brick, BS, Robert H. Cook-Norris, MD, David A

A definitive case of metastatic folliculotropic melanoma

Effect of appearance-based education compared with health-based education on sunscreen use and knowledge: A randomized controlled trial William Tuong,

Serpiginous mycosis fungoides in a 21-year-old man

Pharmacy costs of specialty medications for plaque psoriasis in the United States Eric J. Yang, BS, Kristen M. Beck, MD, Sahil Sekhon, MD, Tina Bhutani,

Kishore L. Jayakumar, BS, Sara S. Samimi, MD

Lichen striatus associated with etanercept treatment of rheumatoid arthritis Viviana Lora, MD, Jean Kanitakis, MD, Alessandra Latini, MD, Carlo Cota,

David M. Lemchak, DO, Oleg E. Akilov, MD, PhD

Myiasis in a giant squamous cell carcinoma

Volume 3, Issue 4, Pages (July 2017)

“Strawberry gums” in sarcoidosis

A survey-based study on nail examinations at an American Academy of Dermatology free skin cancer screening Dayoung Ko, BS, Shari R. Lipner, MD, PhD

SALT II: A new take on the Severity of Alopecia Tool (SALT) for determining percentage scalp hair loss Elise A. Olsen, MD, Douglas Canfield, BS Journal.

Fever, eosinophilia, and a rash

Videocapillaroscopic alterations in erythematotelangiectatic rosacea

Brooke T. Baldwin, BS, Amy Prakash, MD, Neil A. Fenske, MD, Jane L

Infectious rash after riding elephants

A case of adult T-cell leukemia/lymphoma in the Midwest

Cutaneous involvement in multiple myeloma mimicking acral-lentiginous melanoma Antonio Martorell, MD, Fernando Millan-Parrilla, MD, Enrique Gimeno-Carpio,

Rapid onset of CD8+ aggressive T-cell lymphoma during bexarotene therapy in a patient with Sézary syndrome Alexander Kreuter, MD, Peter Altmeyer, MD

Robert Kantor, BS, Prarthana Dalal, BS, David Cella, PhD, Jonathan I

Minichromosome maintenance protein expression in benign nevi, dysplastic nevi, melanoma, and cutaneous melanoma metastases Alan S. Boyd, MD, Bashar Shakhtour,

Lip edema Journal of the American Academy of Dermatology

Seth B. Forman, MD, Tammie C. Ferringer, MD, Steven J

An unusual case of cytotoxic peripheral T-cell lymphoma

Multifocal paraganglioma, mycosis fungoides, and monoclonal B-cell lymphocytosis in association with RAD51C mutation Amrita Goyal, MD, Kevin Gaddis,

Medicaid acceptance among pediatric dermatologists

A case of congenital erosive and vesicular dermatosis with limited involvement Ji Hyun Lee, MD, Sun Young Yoon, MD, Jeong Deuk Lee, MD, Sang Hyun Cho,

Treatment of shiitake dermatitis by balneo PUVA therapy

Modification of the nail psoriasis severity index

Posttransplantation lymphoproliferative disease with features of lymphomatoid granulomatosis in a lung transplant patient Eun Ji Kwon, MD, Kenneth A.

Gordon W. Jung, MD, Patricia T. Ting, MSc, MD, Thomas G

Digital photography in the diagnosis of scabies

Penile condylomata? Traumatic neuromas!

CD4/CD8 double-negative early-stage mycosis fungoides associated with primary cutaneous follicular center lymphoma Jeong Hee Cho-Vega, MD, PhD, Jaime.

A new oral anticoagulant in the setting of dermatologic surgery

Violaceous plaque on the forehead clinically resembling angiosarcoma: Cutaneous metastasis in a patient with prostatic adenocarcinoma John S. Boswell,

Eyebrow transplantation: Alternative body sites as a donor source

Treatment of cutaneous pseudolymphoma with interferon alfa-2b

Gaps in pain management in dermatology: A needs assessment from Canada

Michael Conroy, MD, MS, Lindsay Sewell, MD, O

Randomized study of topical tacrolimus ointment as possible treatment for resistant idiopathic pruritus ani Erwin Suys, MD Journal of the American Academy.

“Boot foot” with pseudomonas colonization

Presentation transcript:

Expression of T-bet and GATA-3 in early mycosis fungoides and spongiotic dermatitis Amira Elbendary, MBBCh, MSc, Kruti Parikh, BS, Inas Elattar, DrPH, Jonathan Truong, HTL, QIHC, BS, Dirk M. Elston, MD Journal of the American Academy of Dermatology Volume 74, Issue 5, Pages 1012-1014 (May 2016) DOI: 10.1016/j.jaad.2015.12.004 Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Expression of GATA-3/CD3 and T-bet/CD3 in spongiotic dermatitis and mycosis fungoides (MF). A, GATA-3/CD3 nuclear expression in reactive lymphocytes in spongiotic dermatitis (original magnification: ×200); B, Nuclear expression of GATA-3/CD3 in epidermotropic atypical lymphocytes in MF (original magnification: ×200); C, Nuclear expression of T-bet/CD3 in reactive lymphocytes in spongiotic dermatitis (original magnification: ×200); D, Expression of T-bet/CD3 in nuclei of atypical epidermotropic lymphocytes in MF (original magnification: ×200). Journal of the American Academy of Dermatology 2016 74, 1012-1014DOI: (10.1016/j.jaad.2015.12.004) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Single staining of GATA-3 (A) and T-bet (B) in case of mycosis fungoides (MF). Note the easy interpretation of T-bet staining, and difficulty in case of GATA-3 due to the brown background staining of the epidermis (original magnification: ×200). Journal of the American Academy of Dermatology 2016 74, 1012-1014DOI: (10.1016/j.jaad.2015.12.004) Copyright © 2015 American Academy of Dermatology, Inc. Terms and Conditions