Genetic predisposition to CHD modifies the increased CHD risk associated with smoking (*) ORs adjusted for age, gender, total energy intake, alcohol intake,

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Presentation transcript:

Genetic predisposition to CHD modifies the increased CHD risk associated with smoking (*) ORs adjusted for age, gender, total energy intake, alcohol intake, leisure-time physical activity, and education. CHD: coronary heart disease defined as fatal or non-fatal myocardial infarction, coronary artery bypass graft, percutaneous coronary intervention, or death because of ischemic heart disease; OR: odds ratio; PRS: polygenic risk score including 50 single-nucleotide polymorphisms that are associated with CHD; Hindy et al. Circ GPM