Lung eosinophilic inflammation and airway hyperreactivity are enhanced by murine anaphylactic, but not nonanaphylactic, IgG1 antibodies Maria Fernanda.

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Presentation transcript:

Lung eosinophilic inflammation and airway hyperreactivity are enhanced by murine anaphylactic, but not nonanaphylactic, IgG1 antibodies Maria Fernanda Macedo-Soares, PhD, Denise M Itami, MSc, Carla Lima, PhD, Adenir Perini, PhD, Eliana L Faquim-Mauro, PhD, Milton A Martins, MD, Mahasti S Macedo, PhD Journal of Allergy and Clinical Immunology Volume 114, Issue 1, Pages 97-104 (July 2004) DOI: 10.1016/j.jaci.2004.03.033

Fig 1 Effect of anaphylactic and nonanaphylactic IgG1 on airway eosinophilic inflammation. Mice were immunized and treated as depicted. Two days after challenge, BAL fluid was collected, and total cell and eosinophil numbers were estimated. Data represent means±SEMs for 4 to 5 animals per group. +P<.05 compared with the IR-418–treated group; ∗P<.05 compared with untreated group. Journal of Allergy and Clinical Immunology 2004 114, 97-104DOI: (10.1016/j.jaci.2004.03.033)

Fig 2 Comparison between EPO activity in the lung tissue from anaphylactic and nonanaphylactic IgG1-reconstituted mice. Lungs from mice described in Fig 1 were homogenized 48 hours after challenge. Data represent means±SEMs for 4 to 5 animals per group. ∗P<.05 for the control, immunosuppressed, and nonanaphylactic IgG1-reconstituted groups compared with the nonsuppressed and anaphylactic IgG1-reconstituted groups. ○, Control group; •, nonsuppressed group; ♢, immunosuppressed group; Δ, anaphylactic IgG1-reconstituted group; ▴ nonanaphylactic IgG1-reconstituted group. Journal of Allergy and Clinical Immunology 2004 114, 97-104DOI: (10.1016/j.jaci.2004.03.033)

Fig 3 Comparison between IL-5 and eotaxin levels in BAL fluid from anaphylactic and nonanaphylactic IgG1-reconstituted mice. Two days after challenge, BAL fluid from all groups of mice were obtained for individual measurement of IL-5 (A) and eotaxin (B) by means of ELISA (horizontal bars, mean values). +P<.05 compared with the IR-418–treated group; ∗P<.05 compared with the untreated group. Journal of Allergy and Clinical Immunology 2004 114, 97-104DOI: (10.1016/j.jaci.2004.03.033)

Fig 4 Effect of IgG1 reconstitution on conductance (A) and dynamic compliance (B) of the respiratory system. Two days after challenge, mice were intravenously injected with different doses of methacholine, and results were expressed as the dose (log) required to reduce Grs (ED50%) and Crs (ED40%; horizontal bars, mean values). +P<.05 compared with the IR-418–treated group; ∗P<.05 compared with the untreated group. Journal of Allergy and Clinical Immunology 2004 114, 97-104DOI: (10.1016/j.jaci.2004.03.033)

Fig 5 OVA- and DNP-specific antibody levels in immunosuppressed or IgG1-reconstituted mice. Two days after challenge, mice were bled, and antibody levels were determined by means of ELISA. Data represent the means±SEMs for 4 to 5 animals per group. ∗P<.05 compared with the respective untreated group. Journal of Allergy and Clinical Immunology 2004 114, 97-104DOI: (10.1016/j.jaci.2004.03.033)