Fig. 1. The human tylosis mutation enhances secretion of AREG

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Fig. 1. The human tylosis mutation enhances secretion of AREG Fig. 1. The human tylosis mutation enhances secretion of AREG. (A) Schematic of the mouse Rhbdf2cub/cub mutation, which results in the loss of the cytosolic N-terminus domain of RHBDF2 (ΔN-RHBDF2). The human tylosis mutation enhances secretion of AREG. (A) Schematic of the mouse Rhbdf2cub/cub mutation, which results in the loss of the cytosolic N-terminus domain of RHBDF2 (ΔN-RHBDF2). (B) Schematic of the human RHBDF2 (p.P189L) mutation in the cytosolic N-terminus domain. (C) Sequencing chromatograms of Rhbdf2+/+, Rhbdf2+/ P159L and Rhbdf2 P159L/P159L mice. Arrows indicate a heterozygous single nucleotide polymorphism (SNP) (CCA/CTA) or homozygous SNP (CTA). (D) Images of Rhbdf2+/+ and Rhbdf2P159L/P159L mice at postnatal day 11. Significant hair loss is visible in Rhbdf2 P159L/ P159L mice as early as day 11. (E) Representative image of an eight-week-old female Rhbdf2P159L/P159L mouse presenting a thin hair coat. Vishnu Hosur et al. Biology Open 2017;6:1174-1179 © 2017. Published by The Company of Biologists Ltd