Results of in vivo competition experiments in a mouse model of systemic infection (median CI values are shown by horizontal lines). Results of in vivo.

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Results of in vivo competition experiments in a mouse model of systemic infection (median CI values are shown by horizontal lines). Results of in vivo competition experiments in a mouse model of systemic infection (median CI values are shown by horizontal lines). The figure reflects the competition index values of the acrA and tolC efflux pump component mutant strains compared with the wild-type EcD64 and JC194 E. cloacae clinical isolates. Decreased fitness is observed when the efflux system is inactivated. (Adapted from reference 89.)‏ Alejandro Beceiro et al. Clin. Microbiol. Rev. 2013; doi:10.1128/CMR.00059-12