Interstitial lung abnormality in stage IV non-small cell lung cancer: A validation study for the association with poor clinical outcome Tetsuro Araki,

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Interstitial lung abnormality in stage IV non-small cell lung cancer: A validation study for the association with poor clinical outcome Tetsuro Araki, Suzanne E. Dahlberg, Tomoyuki Hida, Christine A. Lydon, Michael S. Rabin, Hiroto Hatabu, Bruce E. Johnson, Mizuki Nishino European Journal of Radiology Open Volume 6, Pages 128-131 (January 2019) DOI: 10.1016/j.ejro.2019.03.003 Copyright © 2019 The Authors Terms and Conditions

Fig. 1 Overall survival of patients with and without ILA using Kaplan-Meier estimate. Patients with baseline ILA had significantly shorter OS compared to those without (median OS: 9.95 months [95%CI: 5.88–15.5] vs. 16.95 months [95%CI: 14.65–18.7]; p = 0.0002). European Journal of Radiology Open 2019 6, 128-131DOI: (10.1016/j.ejro.2019.03.003) Copyright © 2019 The Authors Terms and Conditions

Fig. 2 A 55-year-old male smoker with stage IV adenocarcinoma of the lung, with a primary tumor in the right lower lobe (A) and osseous metastasis. Pre-treatment chest CT (A, B) demonstrated underlying interstitial lung abnormalities (ILA) with subpleural interlobular septal thickening, traction bronchiectasis, and volume loss in bilateral lungs predominantly in lower lobes. The patient had worsening shortness of breath and died at 10 months since the diagnosis of lung cancer. European Journal of Radiology Open 2019 6, 128-131DOI: (10.1016/j.ejro.2019.03.003) Copyright © 2019 The Authors Terms and Conditions