Biology of Blood and Marrow Transplantation

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Biology of Blood and Marrow Transplantation
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Presentation transcript:

Biology of Blood and Marrow Transplantation Enhancing the Functional Activity of Natural Killer Cells Against Myeloid Leukemia with the IL-15 Super-Agonist, ALT-803  Folashade Otegbeye, MBChB MPH, Nathan Mackowski, Evelyn Ojo, Stephen Moreton, Marcos de Lima, MD, David Wald, MD PhD  Biology of Blood and Marrow Transplantation  Volume 22, Issue 3, (March 2016) DOI: 10.1016/j.bbmt.2015.11.485 Copyright © 2016 Terms and Conditions

Figure l ALT-8.3 enhances the activity and activating receptor expression pattern of ex vivo expanded NK cells as compared to IL-2. Biology of Blood and Marrow Transplantation 2016 22, DOI: (10.1016/j.bbmt.2015.11.485) Copyright © 2016 Terms and Conditions

Figure 2 ALT-803 injected mice exhibit enhanced afficacy of adoptively transferred NK cells in a mouse AML model system. Biology of Blood and Marrow Transplantation 2016 22, DOI: (10.1016/j.bbmt.2015.11.485) Copyright © 2016 Terms and Conditions

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