Discovery of a small molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying treatment for knee osteoarthritis J.D. Hood, V.

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Presentation transcript:

Discovery of a small molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying treatment for knee osteoarthritis J.D. Hood, V. Deshmukh, C. Barroga, Y. Hu Osteoarthritis and Cartilage Volume 24, Pages S14-S15 (April 2016) DOI: 10.1016/j.joca.2016.01.055 Copyright © 2016 Terms and Conditions

Figure 1 SM04690 induces chondrogenesis in human mesenchymal stem cells. Osteoarthritis and Cartilage 2016 24, S14-S15DOI: (10.1016/j.joca.2016.01.055) Copyright © 2016 Terms and Conditions

Figure 2 SM04690 increases cartilage thickness relative to control in rat instability model. Note:Arrows in Figure 2 designate articular cartilage. Osteoarthritis and Cartilage 2016 24, S14-S15DOI: (10.1016/j.joca.2016.01.055) Copyright © 2016 Terms and Conditions