Dose dependence and time course of the immunologic response to administration of standardized cat allergen extract Anil Nanda, MD, Maeve O'Connor, MD,

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Presentation transcript:

Dose dependence and time course of the immunologic response to administration of standardized cat allergen extract Anil Nanda, MD, Maeve O'Connor, MD, Miriam Anand, MD, Stephen C. Dreskin, MD, PhD, Lening Zhang, PhD, Brittany Hines, MA, Diana Lane, PhD, William Wheat, PhD, John M. Routes, MD, Richard Sawyer, PhD, Lanny J. Rosenwasser, MD, Harold S. Nelson, MD Journal of Allergy and Clinical Immunology Volume 114, Issue 6, Pages 1339-1344 (December 2004) DOI: 10.1016/j.jaci.2004.08.049 Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Total early symptom scores from all doses during titrated nasal challenge at baseline (V1), after 5 weeks, and after 1 year of immunotherapy. The bottom and top edges of the box are located at the 25th and 75th percentiles. The center horizontal line is the median. The bottom and top end of the whiskers show the 20th and 80th percentiles. A significant dose-response relationship exists between increasing dose and decreasing symptoms at 5 weeks (P < .0001) and 1 year (P < .0001). Journal of Allergy and Clinical Immunology 2004 114, 1339-1344DOI: (10.1016/j.jaci.2004.08.049) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Titrated skin prick testing: mean cat allergen concentration (BAU/mL) at baseline, 5 weeks, and 1 year needed to induce a mean wheal size of 5 mm. The dose effect was significant after 5 weeks (P=.014) and after 1 year (P < .0001). Journal of Allergy and Clinical Immunology 2004 114, 1339-1344DOI: (10.1016/j.jaci.2004.08.049) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Median levels of cat-specific IgG4 (μg/mL) at baseline, after 5 weeks, and after 1 year of immunotherapy. The overall dose effect at 5 weeks is significant (P=.004), as are the changes with 3 and 15 μg (P=.03). After 1 year, the overall dose effect is significant (P=.003). Journal of Allergy and Clinical Immunology 2004 114, 1339-1344DOI: (10.1016/j.jaci.2004.08.049) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions