Exercise-induced asthma: Is it the right diagnosis in elite athletes?

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Presentation transcript:

Exercise-induced asthma: Is it the right diagnosis in elite athletes? Sandra D. Anderson, PhD, DSca, Karen Holzer, MB, BSb Journal of Allergy and Clinical Immunology Volume 106, Issue 3, Pages 419-428 (September 2000) DOI: 10.1067/mai.2000.108914 Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 1 Flow chart describing the events leading to cough, mucus production, and EIA. Journal of Allergy and Clinical Immunology 2000 106, 419-428DOI: (10.1067/mai.2000.108914) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 2 The change in FEV1 in relation to the concentration of agonist required to induce this change. Note that the airways are more sensitive to inhalation of leukotriene compared with methacholine or histamine. (Reprinted with permission from Chest. 1997;111[Suppl 2]:27S-34S.) Journal of Allergy and Clinical Immunology 2000 106, 419-428DOI: (10.1067/mai.2000.108914) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 3 The percentage fall in FEV1 before and during treatment with different doses of budesonide administered by means of inhalation. Asterisks denote a significant difference between the percentage fall compared with the control exercise test. Adapted from J Allergy Clin Immunol. 1995;95:29-33. Journal of Allergy and Clinical Immunology 2000 106, 419-428DOI: (10.1067/mai.2000.108914) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 4 The effects of increasing degree of airway smooth muscle contraction on luminal cross-sectional area are shown schematically, and a plot of airflow resistance as a function of dose of agonist is presented for the case of no airway luminal liquid (a, b, c; solid line) and in the presence of liquid-filled interstices (a’, b’, c’; dashed line) . (Reprinted with permission from Am Rev Respir Dis 1991;143[Suppl]:S52-4.) Journal of Allergy and Clinical Immunology 2000 106, 419-428DOI: (10.1067/mai.2000.108914) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 5 Mean value for the percentage change in lung function usually measured as percentage fall in FEV1 or peak expiratory flow after exercise in the presence of a placebo or the active agent. Journal of Allergy and Clinical Immunology 2000 106, 419-428DOI: (10.1067/mai.2000.108914) Copyright © 2000 Mosby, Inc. Terms and Conditions