Guinea pigs fed HFHC diet develop impaired glucose tolerance and suppressed response to insulin. Guinea pigs fed HFHC diet develop impaired glucose tolerance.

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Guinea pigs fed HFHC diet develop impaired glucose tolerance and suppressed response to insulin. Guinea pigs fed HFHC diet develop impaired glucose tolerance and suppressed response to insulin. Fasted or nonfasted guinea pigs were challenged with an oral glucose bolus or exogenous insulin, respectively, and blood glucose was measured over time. (A) Response to an oral glucose challenge in guinea pigs that consumed HFHC diet for 4 or 8 weeks (n=20), compared with normal-diet controls (n=20). Fasting hyperglycemia is absent, but delayed glucose clearance is evident 60 min after glucose challenge in HFHC-fed guinea pigs. *P<0.05, two-way ANOVA. (B) Response of HFHC-fed guinea pigs to an insulin tolerance test (n=5) after 4 or 8 weeks of HFHC feeding or in HFHC/STZ guinea pigs compared with normal-diet controls (n=5). Impaired tissue sensitivity to insulin is apparent in HFHC-fed and HFHC/STZ guinea pigs, based on failure to reduce blood glucose over time compared with normal-diet controls. **P<0.01, based on mean area under the curve, Student's t-test. Brendan K. Podell et al. Dis. Model. Mech. 2017;10:151-162 © 2017. Published by The Company of Biologists Ltd