Ursodeoxycholate/Sulindac combination treatment effectively prevents intestinal adenomas in a mouse model of polyposis  Russell F. Jacoby, Carolyn E. Cole, E.T. Hawk, R.A. Lubet  Gastroenterology  Volume 127, Issue 3, Pages 838-844 (September 2004) DOI: 10.1053/j.gastro.2004.06.003 Copyright © 2004 American Gastroenterological Association Terms and Conditions

Figure 1 Effect of sulindac and ursodeoxycholate on the number of intestinal tumors in Min mice. Animals were treated with these drugs mixed in the diet from age 30 days until death at age 80 days. Tumor numbers in each segment of intestine and colon were quantitated. Bars indicate the total number of tumors per mouse. Data are shown as mean ± SE; n = 8 mice per group. Statistical significance for sulindac 75 ppm treatment alone compared with combined treatment with ursodeoxycholate: +P < 0.05; ++P < 0.01. Statistical significance compared with the control group: *P < 0.05; ** P < 0.01. Gastroenterology 2004 127, 838-844DOI: (10.1053/j.gastro.2004.06.003) Copyright © 2004 American Gastroenterological Association Terms and Conditions