Recruitment of SREBP-1c and Dnmts to the Gpam and Scd1 promoters containing SREs, with changes in histone modification. Recruitment of SREBP-1c and Dnmts.

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Recruitment of SREBP-1c and Dnmts to the Gpam and Scd1 promoters containing SREs, with changes in histone modification. Recruitment of SREBP-1c and Dnmts to the Gpam and Scd1 promoters containing SREs, with changes in histone modification. A: Relative Dnmts mRNA levels in the neonatal (days after birth: 0, 5, and 9) and adult livers (10 weeks of age) examined by quantitative real-time PCR. Values for day 0 were set at 1. n = 3 to 4. B: ChIP analysis. Neonatal (day 0) and adult (10 weeks) livers were used for ChIP analysis with the indicated antibodies. Amplified PCR primers are as shown in Fig. 1B. The top left panel is a representative gel electrophoresis photo. Input is a PCR product from the aliquot of liver lysate before immunoprecipitation (IP). The graphs demonstrate quantitative PCR analysis. The graph of Dnmt1 is not shown because signals from the neonatal and adult livers are lower than the negative control IgG signals. C: ChIP analysis in the Scd1 promoter in the samples used in B. Values of adult sample are set at 1. *P < 0.05, **P < 0.01, ***P < 0.001, n = 3 to 4. Tatsuya Ehara et al. Diabetes 2012;61:2442-2450 ©2012 by American Diabetes Association