Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Thymidylate Synthase and Risk of Pancreatic Cancer  Li Wang, Xiaoping Miao, Wen Tan,

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Genetic Polymorphisms in Methylenetetrahydrofolate Reductase and Thymidylate Synthase and Risk of Pancreatic Cancer  Li Wang, Xiaoping Miao, Wen Tan, Xinghua Lu, Ping Zhao, Xiaohang Zhao, Yi Shan, Hui Li, Dongxin Lin  Clinical Gastroenterology and Hepatology  Volume 3, Issue 8, Pages 743-751 (August 2005) DOI: 10.1016/S1542-3565(05)00156-4 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Overview of the human folate metabolism underlying the importance of folate methyl groups for both DNA methylation and DNA synthesis. DHF, dihydrofolate; THF, tetrahydrofolate; MS, methionine synthase; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; dUMP, deoxyuridine monophosphate; dTMP, thymidine monophosphate. Clinical Gastroenterology and Hepatology 2005 3, 743-751DOI: (10.1016/S1542-3565(05)00156-4) Copyright © 2005 American Gastroenterological Association Terms and Conditions

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