The alveolar compartment in idiopathic pulmonary fibrosis (IPF).

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Presentation transcript:

The alveolar compartment in idiopathic pulmonary fibrosis (IPF). The alveolar compartment in idiopathic pulmonary fibrosis (IPF). Tissue factor (TF) is elevated to a greater extent than tissue factor pathway inhibitor (TFPI) resulting in a procoagulant state. In health, urokinase plasminogen activator (uPA) is abundant. However, elevated plasminogen activator inhibitor (PAI) in IPF prevents plasmin production reducing fibrinolysis and favouring fibrin deposition. Michael G. Crooks, and Simon P. Hart Eur Respir Rev 2015;24:392-399 ©2015 by European Respiratory Society