Correlation of myotube AdipoR1 (A) and AdipoR2 (B) mRNA expression with insulin secretion (n = 40). Correlation of myotube AdipoR1 (A) and AdipoR2 (B) mRNA expression with insulin secretion (n = 40). Data were log transformed to achieve normal distribution (1 AU = 1 ag/100 ng total RNA). First-phase insulin secretion (OGTT) was calculated as described in research design and methods. After adjustment for AdipoR2, AdipoR1 mRNA still correlated with first-phase insulin secretion (r = 0.44, P = 0.0053, ANOVA). After adjustment for AdipoR1, AdipoR2 mRNA did not correlate with first-phase insulin secretion (r = 0.08, P = 0.6323, ANOVA). Harald Staiger et al. Diabetes 2004;53:2195-2201 ©2004 by American Diabetes Association