Comparison of epsilon aminocaproic acid and low-dose aprotinin in cardiopulmonary bypass: efficiency, safety and cost Michael J Ray, PhD, Mark F O’Brien

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Comparison of epsilon aminocaproic acid and low-dose aprotinin in cardiopulmonary bypass: efficiency, safety and cost Michael J Ray, PhD, Mark F O’Brien The Annals of Thoracic Surgery Volume 71, Issue 3, Pages 838-843 (March 2001) DOI: 10.1016/S0003-4975(00)02229-3

Fig 1 Cumulative chest drainage for the first 24 hours postoperatively. No significant difference existed between the treatment groups. Results are expressed as the medians, the error bars represent the 25th and 75th percentiles. Due to measurements being to the nearest 50 mL, medians and ranges for both groups were often identical. (EACA = epsilon aminocaproic acid.) The Annals of Thoracic Surgery 2001 71, 838-843DOI: (10.1016/S0003-4975(00)02229-3)

Fig 2 Cumulative hemoglobin loss for the first 24 hours postoperatively. There was no significant difference between treatment groups. (EACA = epsilon aminocaproic acid.) The Annals of Thoracic Surgery 2001 71, 838-843DOI: (10.1016/S0003-4975(00)02229-3)

Fig 3 Percentage of patients requiring intraoperative and postoperative transfusion in the low-dose aprotinin and epsilon aminocaproic acid (EACA) groups. There was no significant difference between treatment groups. (FFP = fresh frozen plasma.) The Annals of Thoracic Surgery 2001 71, 838-843DOI: (10.1016/S0003-4975(00)02229-3)

Fig 4 The changes from base line levels of troponin I perioperatively. In this and subsequent figures, stage 0 = induction of anesthesia, stage 1 = 30 minutes into bypass, stage 2 = 1 hour after bypass, stage 3 = 4 hours after bypass, stage 4 = 24 hours after bypass. p values refer to the differences between the treatment groups. The Annals of Thoracic Surgery 2001 71, 838-843DOI: (10.1016/S0003-4975(00)02229-3)

Fig 5 The changes from base line levels of neuron specific enolase (NSE) during and after bypass. (EACA = epsilon aminocaproic acid.) The Annals of Thoracic Surgery 2001 71, 838-843DOI: (10.1016/S0003-4975(00)02229-3)

Fig 6 The changes from base line levels of S-100β during and after bypass. The results for the patients with no neurologic deficit are expressed as medians, the error bars representing the 25th and 75th percentiles. The other two series are the individual data points for 2 patients, 1 of whom had perioperative hemiparesis and another who had two grand mal seizures. The Annals of Thoracic Surgery 2001 71, 838-843DOI: (10.1016/S0003-4975(00)02229-3)