Monitoring Mixed Lineage Leukemia Expression May Help Identify Patients with Mixed Lineage Leukemia–Rearranged Acute Leukemia Who Are at High Risk of.

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Monitoring Mixed Lineage Leukemia Expression May Help Identify Patients with Mixed Lineage Leukemia–Rearranged Acute Leukemia Who Are at High Risk of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation Jing Liu, Yu Wang, Lan-Ping Xu, Dai-Hong Liu, Ya-Zhen Qin, Ying-Jun Chang, Kai-Yan Liu, Xiao-Jun Huang Biology of Blood and Marrow Transplantation Volume 20, Issue 7, Pages 929-936 (July 2014) DOI: 10.1016/j.bbmt.2014.03.008 Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 (A) Rate of relapse based on MLL expression at the time of allo-HSCT (P < .001). (B) Leukemia-free survival based on MLL expression at the time of allo-HSCT (P < .001). (C) Overall survival based on MLL expression at the time of allo-HSCT (P < .001). Biology of Blood and Marrow Transplantation 2014 20, 929-936DOI: (10.1016/j.bbmt.2014.03.008) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 (A) ROC analysis of MLL expression and rate of relapse. (B) The rate of relapse based on MLL expression after allo-HSCT (P < .001). (C) Leukemia-free survival after allo-HSCT based on MLL expression (P < .001). (D) Overall survival after allo-HSCT based on MLL expression (P < .001). Biology of Blood and Marrow Transplantation 2014 20, 929-936DOI: (10.1016/j.bbmt.2014.03.008) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Sequential monitoring of MRD in bone marrow specimens. The levels of MRD in consecutive bone marrow samples are shown for 9 patients with a relapse of AL after allo-HSCT. Biology of Blood and Marrow Transplantation 2014 20, 929-936DOI: (10.1016/j.bbmt.2014.03.008) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions