HMR 3339, a novel selective estrogen receptor modulator, reduces total cholesterol, low-density lipoprotein cholesterol, and homocysteine in healthy postmenopausal.

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Presentation transcript:

HMR 3339, a novel selective estrogen receptor modulator, reduces total cholesterol, low-density lipoprotein cholesterol, and homocysteine in healthy postmenopausal women Tatjana E. Vogelvang, M.D., Velja Mijatovic, Ph.D., Peter Kenemans, Ph.D., Tom Teerlink, Ph.D., Marius J. van der Mooren, Ph.D. Fertility and Sterility Volume 82, Issue 6, Pages 1540-1549 (December 2004) DOI: 10.1016/j.fertnstert.2004.05.093 Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Trial profile of the study. Total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, and Lp(a) were determined in the total group of 118 women, whereas homocysteine and endothelin-1 were determined in a subgroup of 96 women (numbers at baseline: placebo: n = 17; HMR 2.5: n = 20; HMR 10: n = 20; HMR 50: n = 20; and Rlx 60: n = 19). N = number of participants; HMR 2.5 = HMR 3339 2.5 mg; HMR 10 = HMR 3339 10 mg; HMR 50 = HMR 3339 50 mg; Rlx = raloxifene 60 mg. Fertility and Sterility 2004 82, 1540-1549DOI: (10.1016/j.fertnstert.2004.05.093) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Mean of the individual percentage change from baseline in total cholesterol concentrations in the five study groups at week 4 and at week 12. The t test for between-group differences: *P<.05, **P<.01, ***P<.001. HMR 2.5 = HMR 3339 2.5 mg; HMR 10 = HMR 3339 10 mg; HMR 50 = HMR 3339 50 mg; Rlx = raloxifene 60 mg. Fertility and Sterility 2004 82, 1540-1549DOI: (10.1016/j.fertnstert.2004.05.093) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 Mean of the individual percentage change from baseline in LDL-cholesterol concentrations in the five study groups at week 4 and at week 12. The t test for between-group differences: *P<.05, **P<.01, ***P<.001. HMR 2.5 = HMR 3339 2.5 mg; HMR 10 = HMR 3339 10 mg; HMR 50 = HMR 3339 50 mg; Rlx = raloxifene 60 mg. Fertility and Sterility 2004 82, 1540-1549DOI: (10.1016/j.fertnstert.2004.05.093) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 4 Mean of the individual percentage change from baseline in triglycerides concentrations in the five study groups at week 4 and at week 12. The t test for between-group differences: *P<.05, **P<.01. HMR 2.5 = HMR 3339 2.5 mg; HMR 10 = HMR 3339 10 mg; HMR 50 = HMR 3339 50 mg; Rlx = raloxifene 60 mg. Fertility and Sterility 2004 82, 1540-1549DOI: (10.1016/j.fertnstert.2004.05.093) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 5 Mean of the individual percentage change from baseline in homocysteine concentrations in the five study groups at week 4 and at week 12. The t test for between-group differences: *P<.05. HMR 2.5 = HMR 3339 2.5 mg; HMR 10 = HMR 3339 10 mg; HMR 50 = HMR 3339 50 mg; Rlx = raloxifene 60 mg. Fertility and Sterility 2004 82, 1540-1549DOI: (10.1016/j.fertnstert.2004.05.093) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions