Spina bifida, diastematomyelia and callosal alterations inSuz12+/−mice

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Spina bifida, diastematomyelia and callosal alterations in Suz12+/−mice. Spina bifida, diastematomyelia and callosal alterations inSuz12+/−mice. (A) In the most impaired cases, Suz12+/− mice showed a protuberated back (white arrowhead) and paraplegia of the posterior legs (yellow arrowhead). (B–D) Suz12 expression in the neural tube (NT) at E8.5 (B), E9.5 (C) and E10.5 (D). (E–H) Malformations observed in the vertebral column of Suz12+/− mice. Diverse degrees of spina bifida (black arrows) were observed in heterozygous mice (F,G) in contrast to wild-type mice (E). In addition, diastematomyelia (H) was also found, caused by bony septa in lumbar L3–L4 vertebrae (white arrowheads). (I–L) Other alterations observed in the brain were deformations of the hippocampal cortex (I,J), partial agenesis of the corpus callosum (black arrows) (K,L), and loss of the gray matter in a gradient (K,L; see also Fig. 3C) that follows the posterior-to-anterior Suz12 expression gradient (Fig. 1D,E), with disorganization of cortical layers in the P-CTX of 24-day-old Suz12+/− mice compared with wild-type brains (K,L). Bars, 500 μm (B–F,I–L); 1 mm (G); 250 μm (H). Xavier Miró et al. Dis. Model. Mech. 2009;2:412-418 ©2009 by The Company of Biologists Limited