Crosslinked hyaluronan hydrogels containing mitomycin C reduce postoperative abdominal adhesions  Yanchun Liu, M.D., Hao Li, M.Sc., Xiao Zheng Shu, Ph.D., Steven D. Gray, M.D., Glenn D. Prestwich, Ph.D.  Fertility and Sterility  Volume 83, Issue 4, Pages 1275-1283 (April 2005) DOI: 10.1016/j.fertnstert.2004.09.038 Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Illustration of the surgical protocols. The two procedures involve placement of hyaluronan (HA) films (left) or application of in situ–crosslinking HA gels (right) to the injured area on the rat uterine horns. One suture was placed 5 mm above the injury to keep the two injured sites well contacted. Two surrounding ties were placed to stabilize the position of the films. (For the gel application procedure, the postclosure injection of hydrogel is not illustrated.) Fertility and Sterility 2005 83, 1275-1283DOI: (10.1016/j.fertnstert.2004.09.038) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Photographic examination of rat uterine horn adhesions. (a) Dulbecco's phosphate-buffered saline buffer treatment; (b) gel (0.31%); (c) gel (0.625%); (d) gel (1.25%). Fertility and Sterility 2005 83, 1275-1283DOI: (10.1016/j.fertnstert.2004.09.038) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 Histological examination of rat uterine horn adhesions. (a) Dulbecco's phosphate-buffered saline buffer treatment; (b) gel (0.31%); (c) gel (0.625%); (d) gel (1.25%). Masson's trichrome staining; scale bar, 100 μm. Fertility and Sterility 2005 83, 1275-1283DOI: (10.1016/j.fertnstert.2004.09.038) Copyright © 2005 American Society for Reproductive Medicine Terms and Conditions