Monitoring of intrathecal oxygen tension during experimental aortic occlusion predicts ultrastructural changes in the spinal cord Anders Hellberg, MDa,

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Presentation transcript:

Monitoring of intrathecal oxygen tension during experimental aortic occlusion predicts ultrastructural changes in the spinal cord Anders Hellberg, MDa, A.Tulga Ulus, MDa, Lennart Christiansson, MDb, Jan Westman, MD, PhDc, Olli Leppänen, MDa, David Bergqvist, MD, PhDa, Sadettin Karacagil, MD, PhDa The Journal of Thoracic and Cardiovascular Surgery Volume 121, Issue 2, Pages 316-323 (February 2001) DOI: 10.1067/mtc.2001.112204 Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Normal ultrastructure from the dorsal horn of the lower thoracic cord of animal 15. Nerve cell in the right part of the figure with nucleolus in the upper right corner. In the neuropile to the left of the nerve cell are two astrocytes with nuclei, one in the lower left corner and the other in the lower center part. In the middle upper left portion, numerous cross-sectioned myelinated axons together with some dendrites and boutons are seen. The tissue seems well preserved. (Original magnification ×8000.) The Journal of Thoracic and Cardiovascular Surgery 2001 121, 316-323DOI: (10.1067/mtc.2001.112204) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Intermediate ischemia-reperfusion injury in the dorsal horn from the lower thoracic cord of animal 10. The perikaryon of a nerve cell in the upper right part of the figure is showing dark degeneration like some neuronal processes in the right part of the figure (arrows). Some empty spaces (e) demonstrate the presence of edema and vacuolized structures. (Original magnification ×8000.) The Journal of Thoracic and Cardiovascular Surgery 2001 121, 316-323DOI: (10.1067/mtc.2001.112204) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Absolute ischemia-reperfusion injury in the ventral horn from the lower thoracic cord of animal 8. Numerous empty spaces (e) consisting of edema and vacuoles are present both intracellularly and extracellularly. Note the dark degenerating myelinated and nonmyelinated processes (arrows). In the right center, a myelinated axon demonstrates separation of myelin lamellae (arrowhead). (Original magnification ×8000.) The Journal of Thoracic and Cardiovascular Surgery 2001 121, 316-323DOI: (10.1067/mtc.2001.112204) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions